Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones
- Correspondence should be addressed to B J Renquist; Email: bjrenquist{at}email.arizona.edu
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Figure 1
Effect of glucoregulatory hormones on hepatic lipid metabolism. Glucagon, cortisol, growth hormone (GH) and norepinephrine (NE) all act counter-regulatory to insulin to affect glucose homeostasis, yet have divergent effects on lipid homeostasis. Hormone signaling can induce an increase in hepatic lipid accumulation through increased adipose tissue lipolysis and hepatic lipid clearance, increased de novo lipogenesis, decreased beta-oxidation or decreased lipid export as VLDL particles. Hormones written in green text activate the indicated pathway, while hormones in red text inhibit the pathway. NEFA–Non-esterified fatty acid, TAG–Triglycerol, LPL–lipoprotein lipase.
- © 2017 Society for Endocrinology
