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Review:
- Nicole M Templeman,
- Søs Skovsø,
- Melissa M Page,
- Gareth E Lim,
- and James D Johnson
A causal role for hyperinsulinemia in obesity J Endocrinol 232 (3) R173-R183, doi: 10.1530/JOE-16-0449 First published online 4 January 2017
.../EBPα and peroxisome proliferator–activated receptor (PPAR) γ (Cook & Cowan 2008, Berry et al. 2014, Lim et al. 2015). Recently, it has also been shown that hyperinsulinemia promotes adipose tissue inflammation in mice, which contributes to disruption of metabolic processes such as de novo lipogenesis in WAT...
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Research:
- João Paulo G Camporez,
- Mohamed Asrih,
- Dongyan Zhang,
- Mario Kahn,
- Varman T Samuel,
- Michael J Jurczak,
- and François R Jornayvaz
Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21 J Endocrinol 226 (3) 207-217, doi: 10.1530/JOE-15-0136 First published online 22 July 2015
...& Maratos-Flier E 2010 Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139 456–463. (doi:10.1053/j.gastro.2010.04.054) Published by Bioscientifica Ltd. Research J P G CAMPOREZ and others Mice lacking Fgf21 are hepatic insulin-resistant 226 :3 216...
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Review:
- Rachel Botchlett,
- Shih-Lung Woo,
- Mengyang Liu,
- Ya Pei,
- Xin Guo,
- Honggui Li,
- and Chaodong Wu
Nutritional approaches for managing obesity-associated metabolic diseases J Endocrinol 233 (3) R145-R171, doi: 10.1530/JOE-16-0580 First published online 11 April 2017
...can result in hypoglycemia, muscle atrophy, or ketoacidosis, whereas overconsumption, in addition to causing weight gain and/or obesity if chronically overconsumed, can lead to disruptions in sleep-wake cycles, increased risk for nonalcoholic fatty liver disease (NAFLD) and insulin resistance (Flowers...
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Research:
- Bel M Galmés-Pascual,
- Antonia Nadal-Casellas,
- Marco Bauza-Thorbrügge,
- Miquel Sbert-Roig,
- Francisco J García-Palmer,
- Ana M Proenza,
- Magdalena Gianotti,
- and Isabel Lladó
17β-estradiol improves hepatic mitochondrial biogenesis and function through PGC1B J Endocrinol 232 (2) 297-308, doi: 10.1530/JOE-16-0350 First published online 24 November 2016
...reported in females of many mammalian species, which may also corroborate a protective role of estrogen (Borrás et al. 2003, 2010, Viña et al. 2005). All in all, estrogen seems to positively influence mitochondrial function and energy homeostasis. The peroxisome proliferator-activated receptor gamma...
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Research:
- Abigail Wolf Greenstein,
- Neena Majumdar,
- Peng Yang,
- Papasani V Subbaiah,
- Rhonda D Kineman,
- and Jose Cordoba-Chacon
Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice J Endocrinol 232 (1) 107-121, doi: 10.1530/JOE-16-0447 First published online 31 October 2016
..., University of Illinois at Chicago, Chicago, Illinois, USA 3Biologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA *(A Wolf Greenstein and N Majumdar contributed equally to this work) Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is the target...
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Review:
- Milos Mraz and
- Martin Haluzik
The role of adipose tissue immune cells in obesity and low-grade inflammation J Endocrinol 222 (3) R113-R127, doi: 10.1530/JOE-14-0283 First published online 8 July 2014
..., and others. Most of Th cells express CD4 and can be further categorized accordingactivation state. Published by Bioscientifica Ltd. their density correlated positively with the incidence of Th17 cells Review M MRAZ and M HALUZIK Role of immune cells in obesity 222 :3 R121nonalcoholic fatty liver disease...
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Review:
- Che-Pei Kung and
- Maureen E Murphy
The role of the p53 tumor suppressor in metabolism and diabetes J Endocrinol 231 (2) R61-R75, doi: 10.1530/JOE-16-0324 First published online 9 September 2016
...of diabetes (Secchiero et al. 2013). Similarly, targeting the peroxisome proliferator-activated receptor-γ (PPARγ) has been a proven strategy for the drug development against obesity and diabetes (Blaschke et al. 2006). PPARγ forms a heterodimer with retinoid X receptor (RXR), and PPARγ/RXR complexes can...
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Regular papers:
- Eriko Inoue,
- Toshihiro Ichiki,
- Kotaro Takeda,
- Hirohide Matsuura,
- Toru Hashimoto,
- Jiro Ikeda,
- Aya Kamiharaguchi,
- and Kenji Sunagawa
Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice J Endocrinol 213 (3) 285-291, doi: 10.1530/JOE-12-0014 First published online 29 March 2012
...diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. Journal of Clinical Endocrinology and Metabolism 89 463–478. (doi:10.1210/jc.2003-030723) Bruun JM, Lihn AS, Pedersen SB & Richelsen B 2005 Monocyte chemoattractant protein-1 release is higher...
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Research:
- Anthony M Belenchia,
- Sarah A Johnson,
- Mark R Ellersieck,
- Cheryl S Rosenfeld,
- and Catherine A Peterson
In utero vitamin D deficiency predisposes offspring to long-term adverse adipose tissue effects J Endocrinol 234 (3) 301-313, doi: 10.1530/JOE-17-0015 First published online 4 July 2017
...); Adip, adiponectin; Avy/a, viable yellow agouti; Cebpa, CCAAT/enhancer-binding protein-alpha; HFD, high-fat diet; IU, in utero; Lep, leptin; LFD, low-fat diet; Pparg, peroxisome proliferator-activated receptor gamma; OG, offspring group (genetic background × postnatal environment); VDD, vitamin D...
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Thematic Review:
- Haiming Cao
Adipocytokines in obesity and metabolic disease J Endocrinol 220 (2) T47-T59, doi: 10.1530/JOE-13-0339
...). In addition, circulating aP2 has also been linked to carotid atherosclerosis in humans (Yeung et al. 2007) and nonalcoholic fatty liver disease (NAFLD; Koh et al. 2009). In NAFLD patients, elevated plasma aP2 levels independently http://.endocrinology-journals.org DOI: 10.1530/JOE-13-0339 2014 Society...

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