Breaking BAT: can browning create a better white?

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   Figure 1

   Different ways leading to browning of white adipose tissue, including immune system, CNS, direct activation, or direct inhibition. AgRP, agouti-related peptide; Cox, cyclooxygenase; GLP1, glucagon-like peptide 1; IL, interleukin; ILC2 cells, type 2 innate lymphoid cells; miRNA, micro ribonucleic acid; POMC, proopiomelanocortin; PPAR, peroxisome proliferator-activated receptors; PTEN, phosphatase and tensin homolog; TGF, transforming growth factor; TLE3, transducin-like enhancer of split 3; 5-HT1, 5-hydroxytryptamine receptor 1.
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   Figure 2

   Estimated energy expenditure generated by fully activated human BAT (Muzik et al. 2013, Devlin 2015) in relation to other every day life events that concern energy uptake or expenditure in kcal (for a 75 kg person (Bassett et al. 1997, Gao et al. 2012)).

• © 2016 Society for Endocrinology