Searching journal content for dimerization (as phrase) in full text.

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  1. Review:
    • Maria Domenica Castellone and
    • Rosa Marina Melillo
    RET-mediated modulation of tumour microenvironment and immune response in MEN2 Endocr Relat Cancer ERC-17-0303, doi:10.1530/ERC-17-0303 first published on 20 September 2017
    ...dimerization and activation of the kinase due to the formation of 106 disulfide bridges between RET monomers, 107 ii) those involving the intracytosolic tyrosine kinase domain that associate with 108 Page 5 of 38 6 MEN2B phenotype. These mutations are believed to affect the stability of 109 RET inac ~~~
  2. Review:
    • Takuma Uo,
    • Stephen R Plymate,
    • and Cynthia C Sprenger
    Allosteric alterations in the androgen receptor and activity in prostate cancer Endocr Relat Cancer 24 (9) R335-R348, doi:10.1530/ERC-17-0108
    ...dimerization f constitutively active f splicing R336Review T Uo et al. Diversity of AR-Vs in prostate cancer DOI: 10.1530/ERC-17-0108 http://.endocrinology-journals.org © 2017 Society for Endocrinology Printed in Great Britain Published by Bioscientifica Ltd. 24:9 anti-AR therapy has been developed ~~~
  3. Commentary:
    • Rodrigo Almeida Toledo
    New HIF2α inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas Endocr Relat Cancer 24 (9) C9-C19, doi:10.1530/ERC-16-0479 first published on 30 June 2017
    ...dimerization of HIF2α and ARNT (HIF-B) are shown. A: PAS (Per-ARNT-Sim) A domain; B: PAS (Per-ARNT-Sim) B domain. bHLH, basic helix-loop-helix domain; HIF2α antagonist, PT2399 and PT2385 (peloton therapeutics); ODD, oxygen-dependent degradation domain; TAD, transactivation domain. A full color versi ~~~
  4. Review:
    • Sangeeta Kumari,
    • Dhirodatta Senapati,
    • and Hannelore V Heemers
    Rationale for the development of alternative forms of androgen deprivation therapy Endocr Relat Cancer 24 (8) R275-R295, doi:10.1530/ERC-17-0121 first published on 31 May 2017
    ...dimerization patterns of AR at AREs (head-to-head vs head-to-tail (Shaffer  et  al. 2004)) as originally thought. Rather, recent ChIP-Seq data have clarified that AR binds to selective AREs because of less stringent sequence requirements for the 3′ hexamer (Sahu et al. 2014). Recent bioinformatics-g ~~~
  5. Review:
    • Frederic Castinetti,
    • Jeff Moley,
    • Lois M Mulligan,
    • and Steven G Waguespack
    A comprehensive review on MEN 2B Endocr Relat Cancer ERC-17-0209, doi:10.1530/ERC-17-0209 first published on 11 July 2017
    ...dimerization (Gujral, et al. 2006; Plaza-Menacho, et al. 2014). In 82 vitro studies indeed suggest that the M918T-mutated receptor can be activated and 83 autophosphorylated in the absence of any ligand. Finally, the M918T-mutated receptor can 84 be further activated by its endogenous ligand, even i ~~~
  6. Thematic Review:
    • Isabel Coutinho,
    • Tanya K Day,
    • Wayne D Tilley,
    • and Luke A Selth
    Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence Endocr Relat Cancer 23 (12) T179-T197, doi:10.1530/ERC-16-0422 first published on 31 October 2016
    ...dimerization of distinct AR mutants. Another mutation that can confer antagonist–agonist switching is F877L, which was found to be activated by enzalutamide in cell lines (Balbas et al. 2013, Joseph et al. 2013, Korpal et  al. 2013). Although this alteration was identified in circulating DNA from a ~~~
  7. Thematic Review:
    • Patricia V Elizalde,
    • Rosalía I Cordo Russo,
    • Maria F Chervo,
    • and Roxana Schillaci
    ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy Endocr Relat Cancer 23 (12) T243-T257, doi:10.1530/ERC-16-0360 first published on 7 October 2016
    ...dimerization loop in domain II (Cho et al. 2003, Garrett et al. 2003). This unique ErbB-2 structure helps to explain the fact that despite the absence of a known ligand that binds ErbB-2 directly, this receptor participates in an extensive network of ligand-induced formation of ErbBs dimers (Graus-P ~~~
  8. Thematic Review:
    • Subing Cao,
    • Yang Zhan,
    • and Yan Dong
    Emerging data on androgen receptor splice variants in prostate cancer Endocr Relat Cancer 23 (12) T199-T210, doi:10.1530/ERC-16-0298 first published on 4 October 2016
    ...dimerization and interactions with cofactors (reviewed in Gelmann 2002, Chan & Dehm 2014). The recruitment and formation of multiple protein complexes are required to activate or repress downstream gene expression. The same rules can be applied to AR-Vs. Several studies indicated that AR-Vs may acti ~~~
  9. Profile:
    • Paramita M Ghosh
    WOMEN IN CANCER PROFILE: From physics to cancer biology and everywhere in between Endocr Relat Cancer 23 (11) P15-P21, doi:10.1530/ERC-16-0382 first published on 7 September 2016
    ...dimerization in breast cancer cells. Assay and Drug Development Technologies 8 27–36. (doi:10.1089/ adt.2009.0208) Klebe RJ, Thomas CA, Grant GM, Grant A & Gosh P 1994 Cytoscription: computer controlled micropositioning of cell adhesion proteins and cells. Journal of Tissue Culture Methods 16 189–19 ~~~
  10. Review:
    • Aleksandra M Ochnik and
    • Robert C Baxter
    Combination therapy approaches to target insulin-like growth factor receptor signaling in breast cancer Endocr Relat Cancer 23 (11) R527-R550, doi:10.1530/ERC-16-0218
    ...dimerization and activity, the dual tyrosine kinase inhibitor – lapatinib – which inhibits HER2 and EGFR activity and T-DMI (an  antibody drug-conjugate of the mAb, trastuzumab and the chemotherapy drug DMI (emtansine)) (Verma et  al. 2012, Mendes et al. 2015), have been developed and are clinically ~~~
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