Figure 2
Proposed model of ligand (HRG)-induced and constitutive ErbB-2 nuclear transport from the cell surface to the nucleus. In this model, the Sec61 translocon, part of the ERAD pathway, associates with ErbB-2 at the endoplasmic reticulum (ER) and extracts full-length ErbB-2 from the membrane bilayer allowing its interaction with importin β1 (Imp β1). The ErbB-2/importin β1 complex then interacts with the nuclear pore protein Nup358, a member of the nuclear pore complex (NPC), which results in ErbB-2 nuclear translocation. NLS, nuclear localization sequence.
