Table 1

Changes in the expression of let-7 family members in human cancer

Family member Cancer type downregulated Cancer type up-regulated Reference
7a Breast Sempere et al. (2007)
Lung Takamizawa et al. (2004), Johnson et al. (2005), and Yanaihara et al. (2006)
Melanoma Muller & Bosserhoff (2008)
Pancreatic Torrisani et al. (2009)
PPNAD Iliopoulos et al. (2009)
Lung a Brueckner et al. (2007)
Lymphoma Nie et al. (2008)
Ovarian a Lu et al. (2007)
7b ALL Mi et al. (2007)
Melanoma Schultz et al. (2008)
Ovarian Nam et al. (2008)
PPNAD Iliopoulos et al. (2009)
Prostate Ozen et al. (2008)
Retinoblastoma Huang et al. (2007)
GIST Subramanian et al. (2008)
Lymphoma Lawrie et al. (2008)
7c Burkitt lymphoma b Leucci et al. (2008)
Lung Johnson et al. (2005), and Tokumaru et al. (2008) c
PPNAD Iliopoulos et al. (2009)
Prostate Ozen et al. (2008)
7d HNSCC Childs et al. (2009)
Ovarian Shell et al. (2007), and Dahiya et al. (2008)
Prostate Ozen et al. (2008)
7e Ovarian Dahiya et al. (2008)
Prostate Ozen et al. (2008)
7f Lung Takamizawa et al. (2004)
Ovarian Dahiya et al. (2008)
Prostate Ozen et al. (2008)
Sarcoma Subramanian et al. (2008)
Breast Yan et al. (2008)
7g Lung Johnson et al. (2005)
PPNAD Iliopoulos et al. (2009)
Prostate Ozen et al. (2008)
7i Ovarian Yang et al. (2008b)
Prostate Ozen et al. (2008)
HNSCC Chang et al. (2008a)
Lymphoma Lawrie et al. (2008)
7b* Mesothelioma Guled et al. (2009)
7e* Mesothelioma Guled et al. (2009)
miR-98 Breast Yan et al. (2008)

  • PPNAD, primary pigmented nodular adrenocortical disease; ALL, acute lymphoblastic leukemia; GIST, gastrointestinal stromal tumors; HNSCC, head and neck squamous cell carcinoma.

  • ↵a Let-7a-3.

  • ↵b Negative for c-myc translocation.

  • ↵c Caused by genetic loss of 21q11–q21.

This Article

  1. Published online before print September 24, 2009, doi: 10.1677/ERC-09-0184 Endocr Relat Cancer vol. 17 no. 1 F19-F36
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