The role of let-7 in cell differentiation and cancer

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   Figure 1

   Regulation of the biogenesis of let-7 by Lin28/Lin28B by three different mechanisms. For details see text.
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   Figure 2

   Scheme to illustrate how miRs affect drug sensitivity of cancer cells. In each case, the miRs are not direct inhibiting proteins but are acting by regulating the mRNAs that code for the proteins shown. The drug resistance that was reported to be affected by a specific miR is indicated by a colored dot next to the miR. For details see text.

• © 2010 Society for Endocrinology