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Research:
- Kechun Tang,
- Teresa Pasqua,
- Angshuman Biswas,
- Sumana Mahata,
- Jennifer Tang,
- Alisa Tang,
- Gautam K Bandyopadhyay,
- Amiya P Sinha-Hikim,
- Nai-Wen Chi,
- Nicholas J G Webster,
- Angelo Corti,
- and Sushil K Mahata
Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice J Endocrinol 232 (2) 137-153, doi: 10.1530/JOE-16-0370 First published online 31 October 2016
...and comparable phosphorylation of TBC1D1 at Thr590 confirm the muscle resistance phenotype that we have reported earlier (Gayen et al. 2009). Fibrosis is increasingly appreciated as a major contributor to metabolic dysregulation in obese humans and type 2 diabetics, and increased expression of collagen...
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Review:
- Alpana Mathur,
- Vivek Kumar Pandey,
- and Poonam Kakkar
PHLPP: a putative cellular target during insulin resistance and type 2 diabetes J Endocrinol 233 (3) R185-R198, doi: 10.1530/JOE-17-0081 First published online 20 April 2017
..., whose understanding can be extended into treatment responses to facilitate targeted drug discovery for T2D and allied metabolic syndromes. Background Type 2 diabetes (T2D), obesity and allied disorders are posing serious health problems that are reaching epidemic proportions worldwide (Nanditha et al...
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Research:
- Juthamard Surapongchai,
- Mujalin Prasannarong,
- Tepmanas Bupha-Intr,
- and Vitoon Saengsirisuwan
Angiotensin II induces differential insulin action in rat skeletal muscle J Endocrinol 232 (3) 547-560, doi: 10.1530/JOE-16-0579 First published online 17 January 2017
...and the metabolic syndrome. Physiology and Behavior 100 525–534. (doi:10.1016/j.physbeh.2010.03.018) DeFronzo RA & Tripathy D 2009 Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32 (Supplement 2) S157–S163. (doi:10.2337/dc09-S302) Deji N, Kume S, Araki S, Isshiki K, Araki...
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Research:
- Guillermo Vazquez-Anaya,
- Bridget Martinez,
- José G Soñanez-Organis,
- Daisuke Nakano,
- Akira Nishiyama,
- and Rudy M Ortiz
Exogenous thyroxine improves glucose intolerance in insulin-resistant rats J Endocrinol 232 (3) 501-511, doi: 10.1530/JOE-16-0428 First published online 15 December 2016
...membrane, to increase the uptake of glucose (Cantó & Auwerx 2013). GLUT4 is an insulin-regulated protein that contributes to whole-body glucose homeostasis, and therefore, is a key target for understanding insulin resistance in type 2 diabetes mellitus (T2DM) (Teixeira et al. 2012). However...
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Research:
- Charlene Diepenbroek,
- Leslie Eggels,
- Mariëtte T Ackermans,
- Eric Fliers,
- Andries Kalsbeek,
- Mireille J Serlie,
- and Susanne E la Fleur
Differential effects of hypercaloric choice diets on insulin sensitivity in rats J Endocrinol 232 (1) 49-57, doi: 10.1530/JOE-16-0265 First published online 17 October 2016
...HFHS-fed rats. These data imply that the palatable component consumed plays a role in the development of site-specific insulin sensitivity. Introduction The prevalence of type 2 diabetes mellitus (T2DM), associated with obesity, is taking epidemic proportions. The molecular drivers involved in the pathogenesis...
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Research:
- R De Matteo,
- D J Hodgson,
- T Bianco-Miotto,
- V Nguyen,
- J A Owens,
- R Harding,
- B J Allison,
- G Polglase,
- M J Black,
- and K L Gatford
Betamethasone-exposed preterm birth does not impair insulin action in adult sheep J Endocrinol 232 (2) 175-187, doi: 10.1530/JOE-16-0300 First published online 7 November 2016
... P & Harding R 2010 Induced preterm birth in sheep: a suitable model for studying the developmental effects of moderately preterm birth. Reproductive Sciences 17 724–733. (doi:10.1177/1933719110369182) DeFronzo RA & Tripathy D 2009 Skeletal muscle insulin resistance is the primary defect in type 2 diabetes...
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Research:
- Maaike M Roefs,
- Françoise Carlotti,
- Katherine Jones,
- Hannah Wills,
- Alexander Hamilton,
- Michael Verschoor,
- Joanna M Williams Durkin,
- Laura Garcia-Perez,
- Melissa F Brereton,
- Laura McCulloch,
- Marten A Engelse,
- Paul R V Johnson,
- Barbara C Hansen,
- Kevin Docherty,
- Eelco J P de Koning,
- and Anne Clark
Increased vimentin in human α- and β-cells in type 2 diabetes J Endocrinol 233 (3) 217-227, doi: 10.1530/JOE-16-0588 First published online 27 March 2017
...) and (B) glucagon (green). Insets show cells double labelled for the islet peptide and vimentin. (C, D) Islet from subject with type 2 diabetes (T2DM) labelled for vimentin (white) and (C) insulin (red) and (D) glucagon (green). Insets show cells double labelled for the islet peptide and vimentin. Scale...
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Review:
- Sergio Di Meo,
- Susanna Iossa,
- and Paola Venditti
Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training J Endocrinol 234 (3) R159-R181, doi: 10.1530/JOE-17-0186
...diabetes mellitus (T2DM), a condition resulting from the metabolic changes associated with excess fat. A pivotal role in T2DM development is played by insulin resistance (IR) that is the reduction of the response of peripheral target tissues to a physiological concentration of insulin. Skeletal muscle...
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Research:
- Marco Hatem-Vaquero,
- Mercedes Griera,
- Andrea García-Jerez,
- Alicia Luengo,
- Julia Álvarez,
- José A Rubio,
- Laura Calleros,
- Diego Rodríguez-Puyol,
- Manuel Rodríguez-Puyol,
- and Sergio De Frutos
Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression J Endocrinol 234 (2) 115-128, doi: 10.1530/JOE-16-0662 First published online 10 May 2017
...proposed that during type 2 diabetes, MS and aging, GLUT4 expression is reduced in peripheral tissue, which may play a role in increasing insulin resistance (Shepherd & Kahn 1999, Gaster et al. 2001, Zeyda & Stulnig 2009). Moreover, some medical therapies for type 2 diabetes-like glitazones are able...
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Review:
- Sergio Di Meo,
- Susanna Iossa,
- and Paola Venditti
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources J Endocrinol 233 (1) R15-R42, doi: 10.1530/JOE-16-0598
...because it causes several diseases and reduces life expectancy. Although it is well known that insulin resistance plays a pivotal role in the development of type 2 diabetes mellitus (the more frequent disease in obese people) the link between obesity and insulin resistance is yet a matter of debate. One...

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