Skeletal energy homeostasis: a paradigm of endocrine discovery
- Karla Suchacki⇑,
- Fiona Roberts,
- Andrea Lovdel ,
- Colin Farquharson,
- Nicholas M Morton,
- Vicky E MacRae and
- Will Cawthorn
- K Suchacki, The Centre for Cardiovascular Science , The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland
- F Roberts, Developmental Biology, The Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland
- A Lovdel , Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland
- C Farquharson, Bone Biology Group, Roslin Institute, Edinburgh, EH25 9PS, United Kingdom of Great Britain and Northern Ireland
- N Morton, Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom of Great Britain and Northern Ireland
- V MacRae, Developmental Biology, University of Edinburgh Roslin Institute, Roslin, United Kingdom of Great Britain and Northern Ireland
- W Cawthorn, Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland
- Correspondence: Karla Suchacki, Email: ksuchack{at}exseed.ed.ac.uk
Abstract
Throughout the last decade, significant developments in cellular, molecular, and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research.
- Received 16 March 2017
- Received in final form 13 April 2017
- Accepted 28 April 2017
- Accepted Preprint first posted online on 28 April 2017
