Abstract

Adipose tissue is an active endocrine organ, and our knowledge of this secretory tissue, in recent years, has led us to completely rethink how our body functions and becomes dysregulated with weight gain. Human adipose tissue appears to act as a multi-functional secretory organ with the capacity to control energy homeostasis through peripheral and central regulation of energy homeostasis. It also plays an important role in innate immunity. However the capability to more than double its original mass to cope with positive energy balance in obesity leads to many pathogenic changes. These changes arise within the adipose tissue as well as inducing secondary detrimental effects on other organs like muscle and liver, including chronic low grade inflammation mediated by adipocytokines (adipokine inflammation). This inflammation is modulated by dietary factors and nutrients including glucose and lipids, as well as gut bacteria in the form of endotoxin or lipopolysaccharide. The aim of this current review is to consider the impact of nutrients such as glucose and lipids on inflammatory pathways, specifically within adipose tissue. Furthermore, to discuss how nutrients such as these can influence adipokine inflammation and consequently insulin resistance, directly through their effects on secretion of adipocytokines (TNFa, IL-6, and resistin) as well as indirectly through increases in endotoxin.