60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years

  1. P E Clayton1,2⇑
  1. 1Centre for Paediatrics and Child Health, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
    2Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, UK
    3Department of Endocrinology, The Christie Hospital NHS Foundation Trust, Manchester, M20 4BX, UK
    4Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, M13 9WL, UK
  1. Correspondence should be addressed to P E Clayton; Email: peter.clayton{at}manchester.ac.uk
  1. View larger version:
    Figure 1

    Timeline of the key events in the understanding of the components that control the hypothalamo-growth hormone axis.

  2. View larger version:
    Figure 2

    Central and peripheral components that regulate the GH axis. NPY, neuropeptide Y; FFA, free fatty acids; GH, growth hormone; IGF1, insulin-like growth factor 1; GHRH, GH-releasing hormone; SRIF, somatotrophin release inhibitory factor.

  3. View larger version:
    Figure 3

    Timeline of key events in the evolution of therapies for GH deficiency and GH excess.

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This Article

  1. Published online before print June 3, 2015, doi: 10.1530/JOE-15-0120 J Endocrinol 226 T123-T140
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