Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance
- Antonio Gonzalez-Bulnes⇑,
- Susana Astiz,
- Cristina Ovilo1,
- Clemente J Lopez-Bote2,
- Raul Sanchez-Sanchez,
- Maria L Perez-Solana,
- Laura Torres-Rovira2,
- Miriam Ayuso2 and
- Jorge Gonzalez3
- Departamento de Reproducción Animal, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain
1Departamento de Mejora Genética Animal, INIA, Ctra. La Coruña km 7.5, Madrid 28040, Spain
2Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid 28040, Spain
3Micros Veterinaria, Campus de Vegazana, Leon 24007, Spain
- Correspondence should be addressed to A Gonzalez-Bulnes; Email: bulnes{at}inia.es
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Figure 1
Effects of transgenerational developmental programming on prenatal growth. Changes over time of pregnancy in the mean values of trunk diameter (A), biparietal diameter (B) and occipito-nasal length (C) of the second generation of offspring from control sows (dashed line) and sows exposed to over- and underfeeding during gestation (continuous and dotted lines respectively). Indications of s.e.m. have been omitted for clarity of the figure. Asterisks denote significant differences (*P<0.001).
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Figure 2
Effects of transgenerational developmental programming on postnatal growth. Changes over time (piglets age) in the mean values of body weight and volume (A and B respectively) and BMIs (BMI1 in C and BMI2 in D) of the second generation of male (black dots) and female (white dots) offspring from control sows (dashed line) and sows exposed to over- and underfeeding during gestation (continuous and dotted lines respectively). Indications of s.e.m. have been omitted for clarity of the figure. Asterisks denote significant differences (*P<0.05 and **P<0.001).
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Figure 3
Effects of transgenerational developmental programming on tissue-characteristics of livers. Histological images of the liver (10× and 40× in the insets) in a piglet of the CONTROL group (A and B) with normal hepatocytes without cytoplasmic changes (periportal fibrosis is a normal feature in the histological architecture of the swine liver) and a piglet of the UNDERFED group (C and D) with microvesicular steatosis in almost all the hepatocytes. A full colour version of this figure available via http://dx.doi.org/10.1530/JOE-14-0217.
- © 2014 Society for Endocrinology
