Androgen actions in the ovary: balance is key
- 1Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, PO Box 693, Rochester,
New York 14642, USA
2Center for Human Reproduction, New York, New York 10021, USA
- Correspondence should be addressed to A Sen; Email: aritro_sen{at}urmc.rochester.edu
Abstract
For many decades, elevated androgens in women have been associated with poor reproductive health. However, recent studies have shown that androgens play a crucial role in women's fertility. The following review provides an overall perspective about how androgens and androgen receptor-mediated actions regulate normal follicular development, as well as discuss emerging concepts, latest perceptions, and controversies regarding androgen actions and signaling in the ovary.
- Received in final form 10 July 2014
- Accepted 17 July 2014
- Made available online as an Accepted Preprint 18 July 2014
- © 2014 Society for Endocrinology
