The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?
- Departments of
1Child Health Care
2General Surgery, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China
3Institute of Pediatric Research, Nanjing Medical University, Nanjing, China
4Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
- (Correspondence should be addressed to X Li at Department of Child Health Care, Nanjing Children's Hospital, Nanjing Medical University; Email: xiaonan6189{at}yahoo.com)
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Figure 1Effect of different diets on body weight from W3 to W16. Data are mean±s.e.m., n=6–9 in each group. aP<0.05 vs NL at every time point, bP<0.05 vs SL from W6 to W16, cP<0.05 vs NL-HF at every time point, and dP<0.05 for SL vs NL at every time point. The body weight of NL-HF rats were higher than NL rats at W15 and W16; there was no difference between SL-FO rats' body weight and NL rats from W12 to W16.
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Figure 2Effect of different diets on energy intake from W3 to W16. Data are mean±s.e.m., n=6–9 in each group. aP<0.05 vs NL at every time point, bP<0.05 vs SL at every time point, and cP<0.05 vs NL-HF at every time point. *P<0.05 vs SL and SL-FO at the corresponding time point.
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Figure 4Effect of different diets on intraperitoneal glucose tolerance test (A and B) and areas under the curve (C and D) at W6 (A and C) and W16 (B and D). Data are mean±s.e.m., n=6–9 in each group. aP<0.05 vs NL, bP<0.05 vs SL, and cP<0.05 vs NL-HF.
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Figure 6Effect of different diets on 11β-hsd1 mRNA expression (A) and enzyme activity (B) in retroperitoneal adipose tissue at W16. Data are mean±s.e.m., n=6–9 in each group. aP<0.05 vs NL, bP<0.05 vs SL and cP<0.05 vs NL-HF.
- © 2012 Society for Endocrinology
