Kisspeptin and fertility

  1. Waljit S Dhillo
  1. Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK
  1. (Correspondence should be addressed to W S Dhillo; Email: w.dhillo{at}imperial.ac.uk)
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    Figure 1

    Diagram of kisspeptin signalling within the female central nervous system. KISS1-expressing neurons within the hypothalamic arcuate nucleus (ARC; equivalent to the infundibular nucleus in primates) are negatively regulated by oestrogen and inhibit GnRH release. KISS1-expressing neurons within the hypothalamic anteroventral periventricular nuclear (AVPV) are positively regulated by oestrogen and stimulate GnRH during the pre-ovulatory surge. Kisspeptin may also have a direct modulatory effect on pituitary LH and FSH release. KISS1 neurons in the ARC co-express neurokinin B (NKB), which stimulates LH and FSH release in a GnRH-dependent manner. Leptin signalling has a permissive effect on kisspeptin signalling within the ARC, which may be mediated by the mammalian target of rapamycin (mTOR; also known as mechanistic target of rapamycin, MTOR) pathway.

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  1. Published online before print November 17, 2010, doi: 10.1677/JOE-10-0265 J Endocrinol 208 97-105
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