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Figure 3
Schematic illustration of the possible role of DKK1 in the bone remodelling imbalance in inflammatory joint disease. Production
of DKK1 in response to TNF-α production by inflammatory cells is proposed to inhibit bone formation but increase bone resorption
by osteoclasts through a suppression of OPG production by osteoblasts.
2008Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nature Clinical Practice. Endocrinology and Metabolism 480–90.
2006Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock. Journal of Clinical Endocrinology and Metabolism 912548–2554.
2007Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen
receptor alpha. Journal of Biological Chemistry 28220715–20727.
1990Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of
dexamethasone. Developmental Biology 140132–138.
2004Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue. Scandinavian Journal of Gasteroenterology 39549–553.
2005Prevalence of and risk factors for low bone mineral density and vertebral fractures in patients with systemic lupus erythematosus. Arthritis and Rheumatism 522044–2050.
2007Alterations in proximal femur geometry in children treated with glucocorticoids for Crohn disease or nephrotic syndrome: impact
of the underlying disease. Journal of Bone and Mineral Research 22551–559.
1998Alterations of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: study in eumenorrheic
patients with Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 831863–1867.
2008Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month,
multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis and Rheumatism 581299–1309.
2001Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from
glucocorticoid inactivation to activation. Journal of Bone and Mineral Research 161037–1044.
200311β-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. Journal of Clinical Endocrinology and Metabolism 883874–3877.
2006The essential role of glucocorticoids for proper human osteoblast differentiation and matrix mineralization. Molecular and Cellular Endocrinology 24887–93.
1996Bone loss in rheumatoid arthritis. Influence of disease activity, duration of the disease, functional capacity, and corticosteroid
treatment. Scandinavian Journal of Rheumatology 25367–376.
2006Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human
fibroblasts: a mechanism for tissue-specific regulation of inflammation. Arthritis Research and Therapy 8R108.
1999Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic
lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1404382–4389.
2000The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. Journal of Bone and Mineral Research 152–12.
1995The effect of glucocorticoids on joint destruction in rheumatoid arthritis. The Arthritis and Rheumatism Council Low-Dose
Glucocorticoid Study Group. New England Journal of Medicine 333142–146.
2000Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL–RANK interaction. Journal of Experimental Medicine 191275–286.
2001Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction
in rheumatoid arthritis patients. Arthritis and Rheumatism 441003–1012.
2004Long-term, high-dose glucocorticoids and bone mineral content in childhood glucocorticoid-sensitive nephrotic syndrome. New England Journal of Medicine 351868–875.
2000RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and
calcium metabolism. PNAS 971566–1571.
2003Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis: a long-term outcome study of one hundred
five patients. Arthritis and Rheumatism 482214–2223.
2002A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. American Journal of Human Genetics 7011–19.
1995Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. New England Journal of Medicine 332305–311.
2000Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation
of the expression by osteotropic factors and cytokines. Biochemical and Biophysical Research Communications 275768–775.
2008Anti-TNF-alpha immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects
with rheumatoid arthritis. Journal of Periodontology 791645–1651.
2002Pre-receptor regulation of glucocorticoid action by 11β-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation. FASEB Journal 1636–44.
2008Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporosis International 19733–759.
2006Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. Journal of Experimental Medicine 2032673–2682.
2008Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption. Seminars in Cell and Developmental Biology 19444–451.
Stegk JP, Ebert B, Martin HJ & Maser E 2009 Expression profiles of human 11β-hydroxysteroid dehydrogenases type 1 and type
2 in inflammatory bowel diseases. Molecular and Cellular Endocrinology301 104–108..
2003The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. New England Journal of Medicine 3492483–2494.
2004Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy. Alimentary Pharmacology and Therapeutics 20951–957.
2001Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 1421982–1989.
2006Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFkappaB ligand serum levels
during treatment with infliximab in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 651495–1499.
2008Modulation of dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone
mass loss. Endocrinology 1491793–1801.
1998Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms
of their deleterious effects on bone. Journal of Clinical Investigation 102274–282.
2002Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. Journal of Clinical Investigation 1091041–1048.
Wetzsteon RJ, Shults J, Zemel BS, Gupta PU, Burnham JM, Herskovitz RM, Howard KM & Leonard MB 2009 Divergent effects of glucocorticoids
on cortical and trabecular compartment bone mineral density in childhood nephrotic syndrome. Journal of Bone and Mineral Research24 503–513..