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Figure 3

Schematic illustration of the possible role of DKK1 in the bone remodelling imbalance in inflammatory joint disease. Production of DKK1 in response to TNF-α production by inflammatory cells is proposed to inhibit bone formation but increase bone resorption by osteoclasts through a suppression of OPG production by osteoblasts.

This Article

  1. J Endocrinol vol. 201 no. 3 309-320