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Figure 2

The canonical Wnt pathway: the wnt pathway increases β-catenin availability. In the absence of Wnt signalling, a destruction complex containing axin, glycogen synthase kinase-3b (GSK-3b), adenomatous polypsis coli (APC) and casein kinase 1 (CK1) targets β-catenin for proteosomal degradation. Wnt signalling is initiated by binding of Wnts to the frizzled (Fz) and LRP5/6 co-receptor complex. Activation causes recruitment of GSK-3β binding protein (GBP), which interferes with β-catenin degradation. β-Catenin accumulates within the cytosol and translocates into the nuclues where it binds to TCF/LEF transcription factors and initiates transcription of Wnt target genes. Several secreted factors inhibit Wnt signalling through binding to Wnts (e.g. secreted Fz related proteins (SFrp) and Wif1) or the LRP5/6 receptor (e.g. DKK1 and sclerostin).

This Article

  1. J Endocrinol vol. 201 no. 3 309-320