• Made available online as an Accepted Preprint 17 November 2010
  • Accepted Preprint first posted online on 17 November 2010

Kisspeptin and fertility

  1. Waljit S Dhillo
  1. Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK
  1. (Correspondence should be addressed to W S Dhillo; Email: w.dhillo{at}imperial.ac.uk)

Abstract

The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic–pituitary–gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and gonadal steroid hormone secretion and the implications of these findings with respect to fertility. In addition, the potential therapeutic use of kisspeptin in the treatment of reproductive disorders will be examined.

  • Received in final form 8 November 2010
  • Accepted 17 November 2010
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This Article

  1. Published online before print November 17, 2010, doi: 10.1677/JOE-10-0265 J Endocrinol 208 97-105
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