What's new in estrogen receptor action in the female reproductive tract
- 1Receptor Biology Group, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes
of Health, Research Triangle Park, North Carolina 27709, USA
2School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA
- Correspondence should be addressed to K S Korach; Email: korach{at}niehs.nih.gov
Abstract
Estrogen receptor alpha (ERα) is a critical player in development and function of the female reproductive system. Perturbations in ERα response can affect wide-ranging aspects of health in humans as well as in livestock and wildlife. Because of its long-known and broad impact, ERα mechanisms of action continue to be the focus on cutting-edge research efforts. Consequently, novel insights have greatly advanced understanding of every aspect of estrogen signaling. In this review, we attempt to briefly outline the current understanding of ERα mediated mechanisms in the context of the female reproductive system.
- Revision received 10 November 2015
- Accepted 19 November 2015
- © 2016 Society for Endocrinology
