Obesity and breast cancer: role of inflammation and aromatase
- 1Metabolism and Cancer Laboratory, Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia Departments of
2Biochemistry and Molecular Biology
3Physiology, Monash University, Clayton, Victoria 3168, Australia
- Correspondence should be addressed to E R Simpson; Email: evan.simpson{at}princehenrys.org
Abstract
Obesity is now recognised to be an inflammatory condition in which dysregulated metabolism plays an integral role. Inflammatory mediators regulate aromatase expression in the human breast as one mechanism whereby they increase the risk of breast cancer, especially in women who are obese.
- Revision received 21 October 2013
- Accepted 23 October 2013
- Made available online as an Accepted Preprint 25 October 2013
- © 2013 Society for Endocrinology
