The regulation and function of the NUAK family
- 1Department of Endocrinology
2Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan, China
3Department of Endocrinology and Metabolism, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan
4Department of Dentistry, School of Dentistry, Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan
5Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
- Correspondence should be addressed to W-C Li or J Zhao; Email: wcli{at}ym.edu.tw or jjzhao{at}medmail.com.cn
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Figure 1
Functional interplay of ARKs. LKB1 often phosphorylates ARKs at threonine 172 (T172) of AMPK and corresponding sites of other ARKs (shown as black bars). After phosphorylation/activation, the AMPK-associated kinases could share common physiological regulation of cell polarity or cell motility by controlling assembly/disassembly of cytoskeletal proteins. Full color version of this figure available via http://dx.doi.org/10.1530/JME-13-0063.
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Figure 2
Cellular and molecular regulatory circuits for (A) NUAK1 and (B) NUAK2. All abbreviations are described in text. Full colour version of this figure available via http://dx.doi.org/10.1530/JME-13-0063.
- © 2013 Society for Endocrinology
