Selective estrogen receptor modulators as brain therapeutic agents

  1. Luis M Garcia-Segura
  1. Instituto CajalCSIC, Avenida Doctor Arce 37, E-28002 Madrid, Spain
    1Departamento de Biología CelularFacultad de Biología, Universidad Complutense de Madrid, E-28040 Madrid, Spain
  1. (Correspondence should be addressed to L M Garcia-Segura; Email: lmgs{at}cajal.csic.es)

Abstract

Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.

  • Revision received October 14, 2010.
  • Accepted November 9, 2010.
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  1. doi: 10.1677/JME-10-0122 J Mol Endocrinol 46 R1-R9
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