Searching journal content for articles similar to Coutinho et al. 23 (12): T179.

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  1. ...-exposed cells exhibited increased expression of cyclin-dependent kinase CDK6 and decreased expression of CDK inhibitors (p21Waf1/CIP1 and p27KIP1). Using specific antagonists for estrogen/androgen receptors, CA in the presence of BPA or its analogues was likely to be mediated via ESR1 signaling. Change...
  2. ... England Journal of Medicine 371 1028–1038. (doi:10.1056/ NEJMoa1315815) Antonarakis ES, Armstrong AJ, Dehm SM & Luo J 2016 Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting. Prostate Cancer and Prostatic Diseases 19 231–241. (doi:10.1038/pcan.2016.17) Asangani IA...
  3. ...fully ERα mediated. Analogous to this, androgen receptor (AR) action is not confined to the prostate alone, but is highly expressed in most breast cancers of both genders. A common feature between male and female breast cancer is that resistance to endocrine therapeutics is frequently observed...
  4. ...pnd bia r, B Abstract prostate " androgen receptor " endocrine therapy resistance Introduction treated with androgen deprivation therapy (ADT), a key remains incurable because resistance rapidly emerges via and/or alternative adaptive 2013). Tumor cell plasticity ivation may play a principal...
  5. ...). The superfamily is commonly broken down, based on Endocrine-Related Cancer (2016) 23, T85–T108 2311 T85–T108 Correspondence should be addressed to C L Bevan Email charlotte.bevan@imperial. ac.uk Key Words f androgen receptor f endocrine therapy resistance f estrogen receptor f gene transcription f prostate f...
  6. ...xas School of Medicine, Shanghai 200120, China protocols targeting both AR and AR PCa cells. Key Words " androgen receptor " prostate cancer instability of cancer cells, generates cellular heterogeneity er et al. 2011, Haffner et al. ing of a castration-resistant prostate tumor foci at the initial...
  7. ...Pharmaceuticals Inc., Carlsbad, California, USA Abstract Androgen receptor (AR) regulation pathways are essential for supporting the growth and survival of prostate cancer cells. Recently, sub-populations of prostate cancer cells have been identified with stem cell features and are associated with the emergence...
  8. ...Can androgen receptor (AR). This has led to the use of anti-androgen therapies that reduce endogenous steroid hormone production as well as the use of AR antagonists. However, the " androgen receptor " endocrine therapy resistance " oncogene Prostate cancer (PCa) is the second most common cancer...
  9. ...resistance of castration-resistant prostate cancer to current therapies and in predicting therapeutic responses. As such, there is an urgent need to target androgen receptor splicing variants for more effective treatment of castrationresistant prostate cancer. Identification of precise and critical targeting...
  10. ...to S M Dehm Email [email protected] Key Words f metastasis f prostate f endocrine therapy resistance f cell lineage/genetics f clonal spread Abstract Metastatic disease is responsible for the majority of prostate cancer deaths. The standard treatment for metastatic disease is surgical or chemical castration...
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