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Thematic Review:
- Hermine Mohr and
- Natalia S Pellegata
Animal models of MEN1 Endocr Relat Cancer 24 (10) T161-T177, doi:10.1530/ERC-17-0249 first published on 25 July 2017
...27) and not in Men1. Both Men1-knockout mice and MENX rats have been exploited for therapy-response studies testing novel drugs for efficacy against neuroendocrine tumors (NETs) and have provided promising leads for novel therapies. In addition to presenting well-established models of MEN1, we also...
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Research Letter:
- L Fishbein,
- S Ben-Maimon,
- S Keefe,
- K Cengel,
- D A Pryma,
- A Loaiza-Bonilla,
- D L Fraker,
- K L Nathanson,
- and D L Cohen
SDHB mutation carriers with malignant pheochromocytoma respond better to CVD Endocr Relat Cancer 24 (8) L51-L55, doi:10.1530/ERC-17-0086 first published on 31 May 2017
...DOI: 10.1530/ERC-17-0086 http://.endocrinology-journals.org © 2017 Society for Endocrinology Printed in Great Britain Published by Bioscientifica Ltd. 24:8 Research Letter L Fishbein et al. Chemotherapy in SDHB mutation carriers 10.1530/ERC-17-0086 Dear Editor, Pheochromocytomas and paragangliomas...
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Review:
- Annunziata Di Domenico,
- Tabea Wiedmer,
- Ilaria Marinoni,
- and Aurel Perren
Genetic and epigenetic drivers of neuroendocrine tumours (NET) Endocr Relat Cancer 24 (9) R315-R334, doi:10.1530/ERC-17-0012 first published on 14 July 2017
... al. 1995). In general, VHL is characterized by increased risk of retinal and central nervous system (CNS) haemangioblastomas, pheochromocytoma (PCC), paragangliomas (PGL), renal clear cell carcinomas, renal cysts, pancreatic NETs (PanNET), pancreatic cysts and endolymphatic sac tumours. Exon 3...
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Review:
- Carole Guerin,
- Pauline Romanet,
- David Taieb,
- Thierry Brue,
- André Lacroix,
- Frederic Sebag,
- Anne Barlier,
- and Frederic Castinetti
Looking beyond the thyroid: advances in understanding of pheochromocytoma and hyperparathyroidism phenotypes in MEN2 and of non-MEN2 familial forms Endocr Relat Cancer ERC-17-0266, doi:10.1530/ERC-17-0266 first published on 5 September 2017
...LOOKING BEYOND THE THYROID - ADVANCES IN UNDERSTANDING OF 1 PHEOCHROMOCYTOMA AND HYPERPARATHYROIDISM PHENOTYPES IN 2 MEN2 AND OF NON-MEN 2 FAMILIAL FORMS 3 4 1*Carole GUERIN, 2*Pauline ROMANET, 3David TAIEB, 4Thierry BRUE, 5André 5 LACROIX, 1Frederic SEBAG, 2Anne BARLIER, 4Frederic CASTINETTI 6 7 1...
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Thematic Review:
- Rami Alrezk,
- Fady Hannah-Shmouni,
- and Constantine A Stratakis
MEN4 and CDKN1B mutations: the latest of the MEN syndromes Endocr Relat Cancer 24 (10) T195-T208, doi:10.1530/ERC-17-0243 first published on 19 August 2017
...is characterized by primary hyperparathyroidism (PHPT) due to parathyroid gland hyperplasia, and functional or nonfunctional pancreatic neuroendocrine tumors (pNETs) and pituitary adenomas (Thakker et al. 2012). MEN2, a less common entity, is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma...
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Research:
- Vanessa D'Antongiovanni,
- Serena Martinelli,
- Susan Richter,
- Letizia Canu,
- Daniele Guasti,
- Tommaso Mello,
- Paolo Romagnoli,
- Karel Pacak,
- Graeme Eisenhofer,
- Massimo Mannelli,
- and Elena Rapizzi
The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids Endocr Relat Cancer 24 (10) 555-564, doi:10.1530/ERC-17-0212
...Institutes of Health, Bethesda, Maryland, USA *(V D’Antongiovanni and S Martinelli contributed equally to this work) Abstract Pheochromocytomas (Pheos) and paragangliomas (PGLs) are neuroendocrine tumors. Approximately 30–40% of Pheos/PGLs are due to germline mutations in one of the susceptibility genes...
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Research Letter:
- Frederic Castinetti,
- Ana Luiza Maia,
- Mariola Peczkowska,
- Marta Barontini,
- Kornelia Hasse-Lazar,
- Thera P Links,
- Rodrigo A Toledo,
- Sarka Dvorakova,
- Caterina Mian,
- Maria Joao Bugalho,
- Stefania Zovato,
- Maria Alevizaki,
- Andrei Kvachenyuk,
- Birke Bausch,
- Paola Loli,
- Simona R Bergmann,
- Attila Patocs,
- Marija Pfeifer,
- Josefina Biarnes Costa,
- Ernst von Dobschuetz,
- Claudio Letizia,
- Gerlof Valk,
- Marcin Barczynski,
- Malgorzata Czetwertynska,
- John T M Plukker,
- Paola Sartorato,
- Tomas Zelinka,
- Petr Vlcek,
- Svetlana Yaremchuk,
- Georges Weryha,
- Letizia Canu,
- Nelson Wohllk,
- Frederic Sebag,
- Martin K Walz,
- Charis Eng,
- and Hartmut P H Neumann
The penetrance of MEN2 pheochromocytoma is not only determined by RET mutations Endocr Relat Cancer 24 (8) L63-L67, doi:10.1530/ERC-17-0189 first published on 25 June 2017
...A and MEN2B are also characterized by the occurrence of pheochromocytoma (PHEO), though less frequent than MTC. PHEO is a chromaffin tumor arising from the medullar zone of the adrenals and responsible for mortality if left undiagnosed (Lenders et al. 2005). Precise comparative large...
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Research:
- Felicity E B May and
- Bruce R Westley
TFF3 is a valuable predictive biomarker of endocrine response in metastatic breast cancer Endocr Relat Cancer 22 (3) 465-479, doi:10.1530/ERC-15-0129 first published on 21 April 2015
...predictive biomarker ofas icen .0 Ubiomarker of endocrine response in metastatic breast cancerTFF3 is a valuable predic Open Accessivee and for frail patients sed under a Creative Commons nported License. et al. 1997), and TFF3 protein is expressed in normal breast Materials and methods Research F E B May...
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Thematic Review:
- Frédéric Castinetti,
- Alexander Kroiss,
- Rakesh Kumar,
- Karel Pacak,
- and David Taieb
15 YEARS OF PARAGANGLIOMA: Imaging and imaging-based treatment of pheochromocytoma and paraganglioma Endocr Relat Cancer 22 (4) T135-T145, doi:10.1530/ERC-15-0175 first published on 4 June 2015
...15 YEARS OF PARAGANGLIOMA Although anatomic imaging to assess the precise localization of pheochromocytomas/ paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these patients with metastatic disease, is based on the periodic use of functional imaging, often Key Words " F...
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Research:
- I Marinoni,
- A Wiederkeher,
- T Wiedmer,
- S Pantasis,
- A Di Domenico,
- R Frank,
- E Vassella,
- A Schmitt,
- and A Perren
Hypo-methylation mediates chromosomal instability in pancreatic NET Endocr Relat Cancer 24 (3) 137-146, doi:10.1530/ERC-16-0554 first published on 23 January 2017
...Marinoni; Email: [email protected] Abstract DAXX and or ATRX loss occur in 40% of pancreatic neuroendocrine tumors (PanNETs). PanNETs negative for DAXX or ATRX show an increased risk of relapse. The tumor-associated pathways activated upon DAXX or ATRX loss and how this event may induce...

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Endocrine-Related Cancer

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