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Research:
- Maria Santa Rocca,
- Andrea Di Nisio,
- Arianna Marchiori,
- Marco Ghezzi,
- Giuseppe Opocher,
- Carlo Foresta,
- and Alberto Ferlin
Copy number variations of E2F1: a new genetic risk factor for testicular cancer Endocr Relat Cancer 24 (3) 119-125, doi:10.1530/ERC-16-0514 first published on 19 January 2017
...Copy number variations of E2F1 : a new genetic risk factor for testicular cancer Maria Santa Rocca 1 , Andrea Di Nisio 1 , Arianna Marchiori 1 , Marco Ghezzi 1 , Giuseppe Opocher 1, 2 , Carlo Foresta 1 and Alberto Ferlin 1 ⇑ 1 Department of Medicine , DIMED University of Padua, Padua, Italy 2...
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Research Letter:
- Luis G Perez-Rivas,
- Andrea Oßwald,
- Thomas Knösel,
- Kristin Lucia,
- Christian Schaaf,
- Michael Hristov,
- Julia Fazel,
- Thomas Kirchner,
- Felix Beuschlein,
- Martin Reincke,
- and Marily Theodoropoulou
Expression and mutational status of USP8 in tumors causing ectopic ACTH secretion syndrome Endocr Relat Cancer 24 (9) L73-L77, doi:10.1530/ERC-17-0054 first published on 14 July 2017
...syndrome. Reviews in Endocrine and Metabolic Disorders 11 117–126. (doi:10.1007/s11154-010-9139-z) Araki T, Liu N-A, Tone Y, Cuevas-Ramos D, Heltsley R, Tone M & Melmed S 2016 E2F1-mediated human POMC expression in ectopic Cushing’s syndrome. Endocrine-Related Cancer 23 857–870. (doi:10.1530/ERC-16...
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Regular papers:
- Dario Palmieri,
- Teresa Valentino,
- Ivana De Martino,
- Francesco Esposito,
- Paolo Cappabianca,
- Anne Wierinckx,
- Michela Vitiello,
- Gaetano Lombardi,
- Annamaria Colao,
- Jacqueline Trouillas,
- Giovanna Maria Pierantoni,
- Alfredo Fusco,
- and Monica Fedele
PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis Endocr Relat Cancer 19 (2) 123-135, doi:10.1530/ERC-11-0135 first published on 23 December 2011
...between PIT1 and(Correspondence should be addressed to A Fusco; Email: [email protected]) Abstract We have previously demonstrated that HMGA1B and HMGA2 overexpression in mice induces the development of GH and prolactin (PRL) pituitary adenomas mainly by increasing E2F1 transcriptional activity...
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Regular papers:
- Petteri Ahtiainen,
- Victoria Sharp,
- Susana B Rulli,
- Adolfo Rivero-Müller,
- Veronika Mamaeva,
- Matias Röyttä,
- and Ilpo Huhtaniemi
Enhanced LH action in transgenic female mice expressing hCGβ-subunit induces pituitary prolactinomas; the role of high progesterone levels Endocr Relat Cancer 17 (3) 611-621, doi:10.1677/ERC-10-0016 first published on 7 May 2010
.../transcription factor E2F1 pathway in the growth response to P4. If extrapolated to humans, and given the importance of endogenous P4 and synthetic progestins in female reproductive functions and their pharmacotherapy, it is relevant to revisit the potential role of these hormones in the origin and growth...
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Research:
- Ivana De Martino,
- Rosa Visone,
- Dario Palmieri,
- Paolo Cappabianca,
- Paolo Chieffi,
- Floriana Forzati,
- Antonio Barbieri,
- Mogens Kruhoffer,
- Gaetano Lombardi,
- Alfredo Fusco,
- and Monica Fedele
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas Endocr Relat Cancer 14 (3) 875-886, doi:10.1677/ERC-07-0036
...to an increased E2F1 activity, directly consequent to the HMGA2Gaetano Lombardi , Alfredo Fusco and Monica Fedele 1Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, University of Naples ‘Federico II’, via Pansini 5, 80131 Naples, Italy 2...
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Review:
- Georgios K Dimitriadis,
- Anna Angelousi,
- Martin O Weickert,
- Harpal S Randeva,
- Gregory Kaltsas,
- and Ashley Grossman
Paraneoplastic endocrine syndromes Endocr Relat Cancer 24 (6) R173-R190, doi:10.1530/ERC-17-0036 first published on 24 March 2017
...cross-sectional imaging (computerised tomography, CT) with a sensitivity and specificity of Table 2 Ectopic Cushing’s syndrome (CS): differences in clinical, laboratory and radiological features compared to eutopic secretion. Syndrome Mediator Tumour Clinical/biochemical Endocrine testing Radiological...
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Thematic Review:
- Hermine Mohr and
- Natalia S Pellegata
Animal models of MEN1 Endocr Relat Cancer 24 (10) T161-T177, doi:10.1530/ERC-17-0249 first published on 25 July 2017
...of the proopiomelanocortin (POMC) promoter (Liu et al. 2011). These animals (Tg: Pomc-Pttg) develop corticotroph adenomas associated with decreased glucocorticoid sensitivity, oversecretion of the corticotroph hormone (ACTH) and subsequent metabolic disturbances similar to the hyportisolism seen in Cushing’s disease...
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Research:
- Giampaolo Trivellin,
- Ricardo R Correa,
- Maria Batsis,
- Fabio R Faucz,
- Prashant Chittiboina,
- Ivana Bjelobaba,
- Darwin O Larco,
- Martha Quezado,
- Adrian F Daly,
- Stanko S Stojilkovic,
- T John Wu,
- Albert Beckers,
- Maya B Lodish,
- and Constantine A Stratakis
Screening for GPR101 defects in pediatric pituitary corticotropinomas Endocr Relat Cancer 23 (5) 357-365, doi:10.1530/ERC-16-0091 first published on 9 March 2016
...showed a synergistic effect only in AtT-20 cells (Fig. 5E and F). Discussion GPR101 has been previously shown to be expressed in hypothalamic neurons expressing proopiomelanocortin (POMC), the precursor of ACTH (Nilaweera et al. 2007, Bagnol 2010). Moreover, GPR101 was shown to mediate...
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Review:
- Lisa D Berman-Booty and
- Karen E Knudsen
Models of neuroendocrine prostate cancer Endocr Relat Cancer 22 (1) R33-R49, doi:10.1530/ERC-14-0393 first published on 27 October 2014
...not express AR, estrogen receptor (ER), PSA (NPEPPS), PAP (REG3b), or keratin but express NSE, epithelial membrane antigen, and carcinoembryonic antigen (van Haaften-Day et al. 1987, Jelbart et al. 1989). These tumors also secrete a number of proopiomelanocortin (POMC)-derived hormones in vivo, including...
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Review:
- Yulong Li and
- William F Simonds
Endocrine neoplasms in familial syndromes of hyperparathyroidism Endocr Relat Cancer 23 (6) R229-R247, doi:10.1530/ERC-16-0059 first published on 20 May 2016
...syndrome resulting from primary thymic or bronchial NET is rare. Adrenocorticotropic hormone (ACTH) secreting and growth hormonereleasing hormone (GHRH) secreting thymic tumors have been reported in MEN1 patients resulting in ectopic Cushing’s syndrome and acromegaly, respectively (Boix et al. 2002...

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