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Research:
- Eric Y Lian,
- Sarah M Maritan,
- Jessica G Cockburn,
- Katayoon Kasaian,
- Mathieu J F Crupi,
- David Hurlbut,
- Steven J M Jones,
- Sam M Wiseman,
- and Lois M Mulligan
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas Endocr Relat Cancer 24 (1) 53-69, doi:10.1530/ERC-16-0393 first published on 21 November 2016
...’s Hospital & University of British Columbia, Vancouver, British Columbia, Canada Abstract The RET receptor tyrosine kinase mediates cell proliferation, survival and migration in embryogenesis and is implicated in the transformation and tumour progression in multiple cancers. RET is frequently mutated...
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Research:
- W Imruetaicharoenchoke,
- A Fletcher,
- W Lu,
- R J Watkins,
- B Modasia,
- V L Poole,
- H R Nieto,
- R J Thompson,
- K Boelaert,
- M L Read,
- V E Smith,
- and C J McCabe
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF Endocr Relat Cancer 24 (9) 459-474, doi:10.1530/ERC-16-0340 first published on 4 July 2017
...known as PTTG1IP or c21orf3) as a proto-oncogene based on the transformation potential of PBF in vitro and its ability to induce tumours in xenograft models (Stratford et al. 2005). We and others have demonstrated that PBF is overexpressed in pituitary, thyroid, breast and colorectal tumours...
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Review:
- Margarida M Moura,
- Branca M Cavaco,
- and Valeriano Leite
RAS proto-oncogene in medullary thyroid carcinoma Endocr Relat Cancer 22 (5) R235-R252, doi:10.1530/ERC-15-0070
...ite1,2,3 2Servic¸o de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal to M M Moura min-saude.pt prognosis, and cases with other RET mutations, which have the most indolent course of the Key Words " RAS proto-oncogene...
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Regular papers:
- Hugo Prazeres,
- Joana P Couto,
- Fernando Rodrigues,
- João Vinagre,
- Joana Torres,
- Vitor Trovisco,
- Teresa C Martins,
- Manuel Sobrinho-Simões,
- and Paula Soares
In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp Endocr Relat Cancer 18 (4) 401-412, doi:10.1530/ERC-10-0258 first published on 6 May 2011
..., and Glu511Lys of undetermined pathogenic significance,Abstract(sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp Hugo Prazeres1,2,4, Joana P Couto1, Fernando Rodrigues3, Joa˜o Vinagre1, Joana Torres1, Vitor Trovisco1, Teresa C Martins2, Manuel Sobrinho-Simo˜es1,4 and Paula...
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Research:
- Katharina Lampichler,
- Patricio Ferrer,
- Greisa Vila,
- Mirjam I Lutz,
- Florian Wolf,
- Engelbert Knosp,
- Ludwig Wagner,
- Anton Luger,
- and Sabina Baumgartner-Parzer
The role of proto-oncogene GLI1 in pituitary adenoma formation and cell survival regulation Endocr Relat Cancer 22 (5) 793-803, doi:10.1530/ERC-15-0109 first published on 28 July 2015
..., Dieguez C, Japon MA & Alvarez CV 2012 Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors. Journal of Clinical Endocrinology and Metabolism 97 E80–E87. (doi:10.1210/jc.2011-2187) Gaston-Massuet C, Andoniadou...
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Review:
- Maria Domenica Castellone and
- Rosa Marina Melillo
RET-mediated modulation of tumour microenvironment and immune response in MEN2 Endocr Relat Cancer ERC-17-0303, doi:10.1530/ERC-17-0303 first published on 20 September 2017
...in all inherited cases of MTC, activating point mutations of 26 the RET proto-oncogene are found. RET encodes for a receptor tyrosine kinase protein 27 endowed with transforming potential on thyroid parafollicular cells. As in other cancer 28 types, microenvironmental factors play a critical role in MTC...
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Research:
- Antonella Verrienti,
- Giovanni Tallini,
- Chiara Colato,
- Amélie Boichard,
- Saula Checquolo,
- Valeria Pecce,
- Marialuisa Sponziello,
- Francesca Rosignolo,
- Dario de Biase,
- Kerry Rhoden,
- Gian Piero Casadei,
- Diego Russo,
- Michela Visani,
- Giorgia Acquaviva,
- Marco Ferdeghini,
- Sebastiano Filetti,
- and Cosimo Durante
RET mutation and increased angiogenesis in medullary thyroid carcinomas Endocr Relat Cancer 23 (8) 665-676, doi:10.1530/ERC-16-0132 first published on 8 July 2016
...-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, et al. 2015 A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. Journal of Biological Chemistry 290 11749–11761. (doi:10.1074/ jbc...
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Research Letter:
- Jessica L Geiger,
- Simion I Chiosea,
- Sue M Challinor,
- Marina N Nikiforova,
- and Julie E Bauman
Primary RET-mutated lung neuroendocrine carcinoma in MEN2B: response to RET-targeted therapy Endocr Relat Cancer 22 (5) L19-L22, doi:10.1530/ERC-15-0307 first published on 18 August 2015
...inheritance of a gain-of-function mutation in the RET proto-oncogene on chromosome 10 (Mulligan & Ponder 1995, Santoro et al. 1995) and is further subclassified into three syndromes based on clinical phenotype: MEN2A (medullary thyroid cancer (MTC), pheochromocytoma, primary parathyroid hyperplasia); MEN2B...
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Research Letter:
- Frederic Castinetti,
- Ana Luiza Maia,
- Mariola Peczkowska,
- Marta Barontini,
- Kornelia Hasse-Lazar,
- Thera P Links,
- Rodrigo A Toledo,
- Sarka Dvorakova,
- Caterina Mian,
- Maria Joao Bugalho,
- Stefania Zovato,
- Maria Alevizaki,
- Andrei Kvachenyuk,
- Birke Bausch,
- Paola Loli,
- Simona R Bergmann,
- Attila Patocs,
- Marija Pfeifer,
- Josefina Biarnes Costa,
- Ernst von Dobschuetz,
- Claudio Letizia,
- Gerlof Valk,
- Marcin Barczynski,
- Malgorzata Czetwertynska,
- John T M Plukker,
- Paola Sartorato,
- Tomas Zelinka,
- Petr Vlcek,
- Svetlana Yaremchuk,
- Georges Weryha,
- Letizia Canu,
- Nelson Wohllk,
- Frederic Sebag,
- Martin K Walz,
- Charis Eng,
- and Hartmut P H Neumann
The penetrance of MEN2 pheochromocytoma is not only determined by RET mutations Endocr Relat Cancer 24 (8) L63-L67, doi:10.1530/ERC-17-0189 first published on 25 June 2017
...SA Jr 1993 Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Human Molecular Genetics 2 851–856. (doi:10.1093/hmg/2.7.851) Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HK, Lips CJ, Nishisho I, Takai SI, et al. 1996 The relationship between specific...
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Research:
- M Cecília Martins-Costa,
- Lucas L Cunha,
- Susan C Lindsey,
- Cleber P Camacho,
- Renata P Dotto,
- Gilberto K Furuzawa,
- M Sharmila A Sousa,
- Teresa S Kasamatsu,
- Ilda S Kunii,
- Márcio M Martins,
- Alberto L Machado,
- João R M Martins,
- Magnus R Dias-da-Silva,
- and Rui M B Maciel
M918V RET mutation causes familial medullary thyroid carcinoma: study of 8 affected kindreds Endocr Relat Cancer 23 (12) 909-920, doi:10.1530/ERC-16-0141
.... Endocrine Related Cancer 18 603–612. (doi:10.1530/ERC-11-0117) Eng C, Smith DP, Mulligan LM, Nagai MA, Healey CS, Ponder MA, Gardner E, Scheumann GF, Jackson CE, Tunnacliffe A, et al. 1994 Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B...

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Endocrine-Related Cancer

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