...advances in the understanding of epithelial ovarian carcinogenesis on a molecular level, complete understanding of the biologic processes underlying malignant transformation of ovarian surface epithelium is lacking. Various hypotheses have been proposed over the past several decades to explain the etiology...

...′-AGACTTGGAAGGCACGAGCAAA-3′); MMP9 (forward 5′-TGCCACTTCCCCTTCATCTTCG-3′; reverse 5′-AAACTGGCAGGGTTTCCCATCA-3′) (Fenouille  et  al. 2012); TWIST1 (forward 5′-GGCTCAGCTACGCCTTCTC-3′; reverse 5′-TCCTTCTCTGGAAACAATGACA-3′) (Sung et al. 2011); ZEB1 (forward 5′-GCACCTGAAGAGGACCAGAG-3′; reverse 5′-TGCATCTGGTGTTCCATTTT-3...

...of patients with DTC. Principles of thyroid carcinogenesis Although w50–67% of the population will eventually present a thyroid nodule during their lives (Mazzaferri 2006, Cronan 2008), the malignant transformation of follicular cells is much less common and thyroid cancers account for no more than 2% of all...

...that the wild-type allele of the Pten gene was progressively lost, whereas carcinogenesis progressed in SAHA-treated ThrbPV/PVPten+/− mice. Thus, this study has uncovered a novel mechanism by which SAHA-induced loss of the tumor suppressor Pten gene to promote thyroid cancer progression. Effectors downstream...

...cells, named medullary ount for 3–5% of all thyroid ssociated with favorable outradioactive iodine therapy, ors show radio- and chemo2009, Grodski & Delbridge Review F Morani et al. Autophagy and thyroid carcinogenesis 21 :1 R13–R29respectively), and a minor portion show a poorlythyroid cancers...

...cells by targeting the PP2A-JNK-Sp1-signaling axis. Carcinogenesis 30 1125–1131. (doi:10.1093/carcin/bgp112) Lu Q, Surks HK, Ebling H, Baur WE, Brown D, Pallas DC & Karas RH 2003 Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A. Journal...

...Willingham and Sheue-yann Cheng Correspondence should be addressedInhibition of STAT3 activ obesity-induced thyroid carcinogenesis in a mousty delays modelwith papillary thyroid mice were obtained by first crossing PtenC/K mice with weeks. They were monitored until they became moribund Research J W Park et...

..., invasion and metastasization (Xing  et  al. 2015, Viola  et  al. 2016). Based on increase in our understanding of the molecular mechanisms underlying thyroid carcinogenesis, including that more aggressive thyroid cancers often show more than one gene alteration (Sobrinho-Simoes et al. 2008, Smallridge...