Searching journal content for high-throughput screening (as phrase) in full text.

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  1. Thematic Review:
    • Hermine Mohr and
    • Natalia S Pellegata
    Animal models of MEN1 Endocr Relat Cancer 24 (10) T161-T177, doi:10.1530/ERC-17-0249 first published on 25 July 2017
    ...high-throughput screening of new putative targets or antitumor agents might be more easily and costeffectively carried out in Drosophila or zebrafish, whereas rodents or PDX models might be better suited for an Figure 5 Pancreatic islets in wild-type and MENX mutant rats. (A) Hematoxylin and eosin ( ~~~
  2. Research:
    • R Formosa,
    • J Borg,
    • and J Vassallo
    Aryl hydrocarbon receptor (AHR) is a potential tumour suppressor in pituitary adenomas Endocr Relat Cancer 24 (8) 445-457, doi:10.1530/ERC-17-0112 first published on 25 June 2017
    ...high-throughput screening method to identify molecular pathways that may be playing a significant and consistent role in PA. RNA profiling using microarrays on eight local PAs identified the aryl hydrocarbon receptor (AHR) signalling pathway as a key canonical pathway downregulated in all PA types. ~~~
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  3. Review:
    • Giovanni Vitale,
    • Germano Gaudenzi,
    • Luisa Circelli,
    • Marco F Manzoni,
    • Andrea Bassi,
    • Niccolò Fioritti,
    • Antongiulio Faggiano,
    • Annamaria Colao,
    • and on behalf of NIKE Group
    Animal models of medullary thyroid cancer: state of the art and view to the future Endocr Relat Cancer 24 (1) R1-R12, doi:10.1530/ERC-16-0399 first published on 31 October 2016
    ...high-throughput screening of novel cancer drugs, as well as to test multi-targeted agents and combination therapy (Dar et  al. 2012, Das et  al. 2014, Yadav et  al. 2016). However, the employment of Drosophila for studies on MTC has several limitations that need to be considered. Indeed, the short l ~~~
  4. Thematic Review:
    • John W Cassidy,
    • Ankita S Batra,
    • Wendy Greenwood,
    • and Alejandra Bruna
    Patient-derived tumour xenografts for breast cancer drug discovery Endocr Relat Cancer 23 (12) T259-T270, doi:10.1530/ERC-16-0251 first published on 4 October 2016
    ...high-throughput screening f patient-derived tumour xenografts f targeted therapies f pharmacogenomics Introduction Breast cancer (herein BC) is not a single disease, but is instead a collection of diseases that have distinct histopathological features and genetic and genomic variability linked to di ~~~
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  5. Research:
    • Sun Wook Cho,
    • Young A Kim,
    • Hyun Jin Sun,
    • Ye An Kim,
    • Byung-Chul Oh,
    • Ka Hee Yi,
    • Do Joon Park,
    • and Young Joo Park
    CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma Endocr Relat Cancer 23 (2) 113-124, doi:10.1530/ERC-15-0196 first published on 11 November 2015
    ...high-throughput screening ~~~
  6. Research Letter:
    • Peter M Sadow,
    • Dora Dias-Santagata,
    • Zongli Zheng,
    • Derrick T Lin,
    • Long Phi Le,
    • and Carmelo Nucera
    Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis Endocr Relat Cancer 22 (6) L23-L28, doi:10.1530/ERC-15-0198
    ...high-throughput screening which is fundamental to identify genomic alterations potentially causative of thyroid cancer progression and drug-resistance. The resulting genomic variants were filtered (Supplementarybrain magnetic resonance imaging (MRI) confirmed a Published by Bioscientifica Ltd. -fi f ~~~
  7. Review:
    • Wei Wei and
    • Michael T Lewis
    Identifying and targeting tumor-initiating cells in the treatment of breast cancer Endocr Relat Cancer 22 (3) R135-R155, doi:10.1530/ERC-14-0447 first published on 15 April 2015
    ...high-throughput screening . Cell 138 645 – 659 . ( doi:10.1016/j.cell.2009.06.034 ). ↵ Gupta PB , Fillmore CM , Jiang G , Shapira SD , Tao K , Kuperwasser C & Lander ES 2011 Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells . Cell 146 633 – 644 . ( d ~~~
  8. Research:
    • Amit Mehta,
    • Lisa Zhang,
    • Myriem Boufraqech,
    • Yaqin Zhang,
    • Dhaval Patel,
    • Min Shen,
    • and Electron Kebebew
    Carfilzomib is an effective anticancer agent in anaplastic thyroid cancer Endocr Relat Cancer 22 (3) 319-329, doi:10.1530/ERC-14-0510
    ...high-throughput screening " carfilzomib " proteasome inhibitor (ATC) accounts for 1–2% of all thyroid cancers, but is the on. ATC is one of the most d has a median survival of only 5 months, and fewer than 20% of patients with ATC Current treatment regimens long-term clinical benefits ta et al. 2013 ~~~
  9. Review:
    • Yevgeniya Kushchayeva,
    • Kirk Jensen,
    • Kenneth D Burman,
    • and Vasyl Vasko
    Repositioning therapy for thyroid cancer: new insights on established medications Endocr Relat Cancer 21 (3) R183-R194, doi:10.1530/ERC-13-0473 first published on 20 January 2014
    ...high-throughput screening using drug libraries and computational network analysis. Recent studies have shown that these experimental methods enable the prediction of novel drug targets and the repositioning of known drugs for the treatment of cancer (Shim et al. 2012, Emig et al. 2013). Studies of t ~~~
  10. Thematic Review:
    • Kevin C Knower,
    • Sarah Q To,
    • Yuet-Kin Leung,
    • Shuk-Mei Ho,
    • and Colin D Clyne
    Endocrine disruption of the epigenome: a breast cancer link Endocr Relat Cancer 21 (2) T33-T55, doi:10.1530/ERC-13-0513 first published on 14 February 2014
    ...high-throughput screening of the epigenome-targeting gene promoters would therefore be the best measurement of PFOA epigenetic targets. Such a study has not been conducted using mouse or human breast models, however this line of investigation worthy of pursuance. DDT and DDE Dichlorodiphenyltrichlor ~~~
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