Searching journal content for MENX (as phrase) in full text.

Displaying results 1-10 of 13
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  1. Thematic Review:
    • Rachel S van Leeuwaarde,
    • Joanne M de Laat,
    • Carolina R C Pieterman,
    • Koen Dreijerink,
    • Menno R Vriens,
    • and Gerlof D Valk
    The future: medical advances in MEN1 therapeutic approaches and management strategies Endocr Relat Cancer 24 (10) T179-T193, doi:10.1530/ERC-17-0225 first published on 2 August 2017
    ...the pancreatic neuroendocrine tumors (pNET). For this reason, after identifying these mutations, a new endocrine tumor syndrome was referred to as MENX or, more recently, MEN4 (Thakker 2014). In a recent nationwide study, major differences in the clinical course were found between 30 mutationnegative MEN1 ~~~
  2. Thematic Review:
    • Hermine Mohr and
    • Natalia S Pellegata
    Animal models of MEN1 Endocr Relat Cancer 24 (10) T161-T177, doi:10.1530/ERC-17-0249 first published on 25 July 2017
    .... Mouse models of MEN1 closely resemble the human disease in terms of tumor spectrum and associated hormonal changes, although individual tumor frequencies are variable. Rats affected by the MENX (MEN1-like) syndrome share some features with MEN1 patients albeit they bear a germline mutation in Cdkn1b (p ~~~
  3. Thematic Review:
    • Rami Alrezk,
    • Fady Hannah-Shmouni,
    • and Constantine A Stratakis
    MEN4 and CDKN1B mutations: the latest of the MEN syndromes Endocr Relat Cancer 24 (10) T195-T208, doi:10.1530/ERC-17-0243 first published on 19 August 2017
    ...and pituitary adenomas. Approximately 10% of patients with familial or sporadic MEN1-like phenotype do not have MEN1 mutations or deletions. A novel MEN syndrome was discovered, initially in rats (MENX), and later in humans (MEN4), which is caused by germline mutations in the putative tumor suppressor CDKN1B ~~~
  4. Thematic Review:
    • Koen M A Dreijerink,
    • H T Marc Timmers,
    • and Myles Brown
    Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1 Endocr Relat Cancer 24 (10) T135-T145, doi:10.1530/ERC-17-0281 first published on 15 August 2017
    ...MENX ~~~
  5. Thematic Review:
    • Sunita K Agarwal
    The future: genetics advances in MEN1 therapeutic approaches and management strategies Endocr Relat Cancer 24 (10) T119-T134, doi:10.1530/ERC-17-0199
    ...-dependent kinase inhibitor (CDKI) gene CDKN1B/p27 in a rat strain with combined MEN1 and MEN2 features (MENX) prompted the germline mutation analysis of this gene in human patients with MEN1-like features, and the identification of the MEN4 disorder (Pellegataetal. 2006). Heterozygous germline mutations in p27 ~~~
  6. Review:
    • Carole Guerin,
    • Pauline Romanet,
    • David Taieb,
    • Thierry Brue,
    • André Lacroix,
    • Frederic Sebag,
    • Anne Barlier,
    • and Frederic Castinetti
    Looking beyond the thyroid: advances in understanding of pheochromocytoma and hyperparathyroidism phenotypes in MEN2 and of non-MEN2 familial forms Endocr Relat Cancer ERC-17-0266, doi:10.1530/ERC-17-0266 first published on 5 September 2017
    ...-10% patients without menin mutations. A subgroup 454 of these patients (roughly 2%) present with CDKN1B (p27) mutations. Identification 455 of p27 mutations were based on a naturally occurring MEN1 rat model (MENX) 456 presenting with an 8 bp homozygous frameshift insertion leading to a premature stop 457 ~~~
  7. Research:
    • Misu Lee,
    • Ninelia Minaskan,
    • Tobias Wiedemann,
    • Martin Irmler,
    • Johannes Beckers,
    • Behrooz H Yousefi,
    • Georgios Kaissis,
    • Rickmer Braren,
    • Iina Laitinen,
    • and Natalia S Pellegata
    Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo Endocr Relat Cancer 24 (1) 1-15, doi:10.1530/ERC-16-0324 first published on 3 November 2016
    ...the need to identify the effective therapeutic approaches for PCC, we evaluated the antitumor potential of the dual-PI3K/mTOR inhibitor BEZ235 against these tumors. We employed an in vivo model of endogenous PCCs (MENX mutant rats), which closely recapitulate the human tumors. Mutant rats with PCCs were ~~~
  8. Thematic Review:
    • Samuel M O'Toole,
    • Judit Dénes,
    • Mercedes Robledo,
    • Constantine A Stratakis,
    • and Márta Korbonits
    15 YEARS OF PARAGANGLIOMA: The association of pituitary adenomas and phaeochromocytomas or paragangliomas Endocr Relat Cancer 22 (4) T105-T122, doi:10.1530/ERC-15-0241 first published on 25 June 2015
    ...occurring within the first year of life in a SpragueDawley rat colony (Fritz et al. 2002). This syndrome, termed MENX, consisted of bilateral phaeo, paraganglioma, parathyroid hyperplasia and pituitary adenomas preceded by juvenile cataracts. Despite the clear overlap in clinical features with both MEN1 ~~~
  9. Research:
    • Albert Beckers,
    • Maya Beth Lodish,
    • Giampaolo Trivellin,
    • Liliya Rostomyan,
    • Misu Lee,
    • Fabio R Faucz,
    • Bo Yuan,
    • Catherine S Choong,
    • Jean-Hubert Caberg,
    • Elisa Verrua,
    • Luciana Ansaneli Naves,
    • Tim D Cheetham,
    • Jacques Young,
    • Philippe A Lysy,
    • Patrick Petrossians,
    • Andrew Cotterill,
    • Nalini Samir Shah,
    • Daniel Metzger,
    • Emilie Castermans,
    • Maria Rosaria Ambrosio,
    • Chiara Villa,
    • Natalia Strebkova,
    • Nadia Mazerkina,
    • Stéphan Gaillard,
    • Gustavo Barcelos Barra,
    • Luis Augusto Casulari,
    • Sebastian J Neggers,
    • Roberto Salvatori,
    • Marie-Lise Jaffrain-Rea,
    • Margaret Zacharin,
    • Beatriz Lecumberri Santamaria,
    • Sabina Zacharieva,
    • Ee Mun Lim,
    • Giovanna Mantovani,
    • Maria Chaira Zatelli,
    • Michael T Collins,
    • Jean-François Bonneville,
    • Martha Quezado,
    • Prashant Chittiboina,
    • Edward H Oldfield,
    • Vincent Bours,
    • Pengfei Liu,
    • Wouter W de Herder,
    • Natalia Pellegata,
    • James R Lupski,
    • Adrian F Daly,
    • and Constantine A Stratakis
    X-linked acrogigantism syndrome: clinical profile and therapeutic responses Endocr Relat Cancer 22 (3) 353-367, doi:10.1530/ERC-15-0038 first published on 24 February 2015
    ...MENX ~~~
  10. Research:
    • Misu Lee,
    • Amelie Lupp,
    • Nigel Mendoza,
    • Niamh Martin,
    • Rudi Beschorner,
    • Jürgen Honegger,
    • Jürgen Schlegel,
    • Talia Shively,
    • Elke Pulz,
    • Stefan Schulz,
    • Federico Roncaroli,
    • and Natalia S Pellegata
    SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary Endocr Relat Cancer 22 (1) 111-119, doi:10.1530/ERC-14-0472 first published on 16 December 2014
    ...Pathology 36 242252. (doi:10.1097/PAS.0b013e31823d07f3) Lee M, Marinoni I, Irmler M, Psaras T, Honegger JB, Beschorner R, Anastasov N, Beckers J, Theodoropoulou M, Roncaroli F et al. 2013 Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved ~~~
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