Searching journal content for Fanconi anemia (as phrase) in full text.

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  1. Thematic Review:
    • Sock Hoai Chan and
    • Joanne Ngeow
    Germline mutation contribution to chromosomal instability Endocr Relat Cancer 24 (9) T33-T46, doi:10.1530/ERC-17-0062
    ...& Bartek 2009, Dexheimer 2013). In general, germline alterations in any of these pathways predispose to an elevated risk of cancer. Many human cancer predisposition syndromes such as Fanconi anemia, ataxia-telangiectasia, Nijmegen breakage syndrome, Bloom syndrome and HNPCC are associated with inherited ~~~
  2. Thematic Review:
    • Yoko Katsuki and
    • Minoru Takata
    Defects in homologous recombination repair behind the human diseases: FA and HBOC Endocr Relat Cancer 23 (10) T19-T37, doi:10.1530/ERC-16-0221 first published on 22 August 2016
    ...Abstract Hereditary breast and ovarian cancer (HBOC) syndrome and a rare childhood disorder Fanconi anemia (FA) are caused by homologous recombination (HR) defects, and some of the causative genes overlap. Recent studies in this field have led to the exciting development of PARP inhibitors as novel cancer ~~~
  3. Thematic Review:
    • Kiranjit K Dhillon,
    • Ilirjana Bajrami,
    • Toshiyasu Taniguchi,
    • and Christopher J Lord
    Synthetic lethality: the road to novel therapies for breast cancer Endocr Relat Cancer 23 (10) T39-T55, doi:10.1530/ERC-16-0228 first published on 15 August 2016
    ...Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Research 63 2688–2694. Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, et al. 2013 Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Disco ~~~
  4. Thematic Review:
    • Amélie Fradet-Turcotte,
    • Justine Sitz,
    • Damien Grapton,
    • and Alexandre Orthwein
    BRCA2 functions: from DNA repair to replication fork stabilization Endocr Relat Cancer 23 (10) T1-T17, doi:10.1530/ERC-16-0297 first published on 16 August 2016
    ...the emergence of several human pathologies including cancer. The breast cancer susceptibility gene 2 (BRCA2, also known as the Fanconi anemia (FA) complementation group D1 (FANCD1)) is a potent tumor suppressor that has been extensively studied in DNA double-stranded break (DSB) repair by homologous ~~~
  5. Thematic Review:
    • Louis de Mestier,
    • Jean-Baptiste Danset,
    • Cindy Neuzillet,
    • Vinciane Rebours,
    • Jérôme Cros,
    • Nadem Soufir,
    • and Pascal Hammel
    Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers Endocr Relat Cancer 23 (10) T57-T67, doi:10.1530/ERC-16-0269 first published on 10 August 2016
    ...M & PetersenG 2005 Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Cancer Research 65 383386. CouchFJ, JohnsonMR, RabeKG, BruneK, de AndradeM, GogginsM, RothenmundH, GallingerS, KleinA, PetersenGM, etal. 2007 The prevalence of BRCA2 mutations in familial ~~~
  6. Editorial:
    • William D Foulkes and
    • Kokichi Sugano
    BRCA2: a grown-up cancer susceptibility gene Endocr Relat Cancer 23 (10) E1-E3, doi:10.1530/ERC-16-0354
    ...is the reminder that BRCA2 links DSB to inter-strand crosslink repair, a central function of the Fanconi Anemia family of proteins. Indeed, one of the most striking developments in BRCA2-related research was the discovery by Alan DAndreas group that biallelic mutations in BRCA2 lead to a subtype of Fanconi ~~~
  7. Commentary:
    • Lisa Bodei,
    • Irvin M Modlin,
    • Markus Luster,
    • Flavio Forrer,
    • Marta Cremonesi,
    • Rodney J Hicks,
    • Samer Ezziddin,
    • Mark Kidd,
    • and Arturo Chiti
    Myeloid neoplasms after chemotherapy and PRRT: myth and reality Endocr Relat Cancer 23 (8) C1-C7, doi:10.1530/ERC-16-0258 first published on 28 June 2016
    ...genetic predisposition (Kitamura etal. 2014). The likelihood of an intrinsic molecular genomic basis is further supported by the increased incidence of myeloid neoplasia in Fanconi anemia, LiFraumeni syndrome, neurofibromatosis type 1, Down syndrome, as well as in circumstances characterized by genetic ~~~
  8. Review:
    • Diana Lim and
    • Joanne Ngeow
    Evaluation of the methods to identify patients who may benefit from PARP inhibitor use Endocr Relat Cancer 23 (6) R267-R285, doi:10.1530/ERC-16-0116 first published on 25 May 2016
    ...genes, including ATM, ATR, BARD1, BRIP1, MRE11A, PALB2, RAD50, RAD51D, RAD54, NBS1, CHEK1, and CHEK2, as well as components of the Fanconi anemia repair pathway (Hughes-Davies et al. 2003, Taniguchi etal. 2003, Venkitaraman 2003, Dedes et al. 2011, Loveday etal. 2011, Rigakos & Razis 2012, Strom ~~~
  9. Editorial:
    • Deborah J Marsh
    Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets Endocr Relat Cancer 22 (1) E1-E3, doi:10.1530/ERC-14-0585 first published on 30 December 2014
    ...substrates, known as monoubiquitination, has also been shown to have critical cellular functions. An example of this is monoubiquitination of the Fanconi Anemia protein FANCD2 in response to DNA damage that promotes homologous recombination repair of DNA double strand breaks (Nakanishi et al. 2005 ~~~
  10. Review:
    • Sandra Rodríguez-Rodero,
    • Elías Delgado-Álvarez,
    • Agustín F Fernández,
    • Juan L Fernández-Morera,
    • Edelmiro Menéndez-Torre,
    • and Mario F Fraga
    Epigenetic alterations in endocrine-related cancer Endocr Relat Cancer 21 (4) R319-R330, doi:10.1530/ERC-13-0070 first published on 4 June 2014
    ...) and Barreau et al. (2013) hosphatase and tensin homolog; TIMP3, TIMP metallopeptidase inhibitor; st cancer 1; FHIT, fragile histidine triad protein; FANCF, Fanconi anemia gene thyltransferase; CDH1, E-cadherin gene; SPARC, secreted protein, acidic, in gene 2. Published by Bioscientifica Ltd. a relationship ~~~
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