Acromegaly is associated with increased cancer risk: a survey in Italy
- Massimo Terzolo1,
- Giuseppe Reimondo1⇑,
- Paola Berchialla2,
- Emanuele Ferrante3,
- Elena Malchiodi3,
- Laura De Marinis4,
- Rosario Pivonello5,
- Silvia Grottoli6,
- Marco Losa7,
- Salvatore Cannavo8,
- Diego Ferone9,
- Marcella Montini10,
- Marta Bondanelli11,
- Ernesto De Menis12,
- Chiara Martini13,
- Efisio Puxeddu14,
- Antonino Velardo15,
- Alessandro Peri16,
- Marco Faustini-Fustini17,
- Patrizia Tita18,
- Francesca Pigliaru19,
- Giulia Peraga1,
- Giorgio Borretta20,
- Carla Scaroni21,
- Nicoletta Bazzoni22,
- Antonio Bianchi4,
- Alessandro Berton6,
- Andreea Liliana Serban3,
- Roberto Baldelli23,
- Letizia Maria Fatti24,
- Annamaria Colao5,
- Maura Arosio3,
- for the Italian Study Group of Acromegaly*
- 1Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy
- 2Statistical Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy
- 3Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
- 4Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy
- 5Division of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II di Napoli, Naples, Italy
- 6Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, ASOU Città della Salute e della Scienza, Turin, Italy
- 7Pituitary Unit, Department of Neurosurgery, San Raffaele Scientific Institute, University ‘Vita- Salute’, Milan, Italy
- 8Department of Clinical and Experimental Medicine-Endocrinology Unit, University of Messina, Messina, Italy
- 9Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), Center of Excellence for Biomedical Research (CEBR) IRCCS, AOU San Martino-IST, San Martino Hospital, University of Genova, Genova, Italy
- 10Ambulatori di Endocrinologia, Humanitas Gavazzeni, Bergamo, Italy
- 11Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
- 12Internal Medicine, San Valentino Hospital, Montebelluna, Treviso, Italy
- 13Internal Medicine, Department of Medicine, DIMED, University of Padova, Padova, Italy
- 14Department of Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
- 15Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Modena, Modena, Italy
- 16Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
- 17IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy
- 18Endocrinology, AO Garibaldi-Nesima, Catania, Italy
- 19Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
- 20Division of Endocrinology and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy
- 21Endocrinology Unit, Department of Medicine, DIMED University of Padua, Padua, Italy
- 22Endocrinology, Sant’Antonio Abate Hospital, Gallarate, Varese, Italy
- 23Endocrinology Unit A.O. San Camillo - Forlanini, Rome, Italy
- 24Division of Endocrine and Metabolic Diseases, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy
- Correspondence should be addressed to G Reimondo; Email: giuseppe.reimondo{at}unito.it
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Figure 1
Sample size of the population-based studies on acromegaly and cancer. Black bars indicate studies showing a positive association between acromegaly and cancer, striped bars indicate negative studies, and white bars indicate studies that do not conclude whether an association is either present or not. Studies which focus on mortality only are marked by the letter M. 1, Mustacchi & Shimkin (1957); 2, Wright et al. (1970); 3, Alexander et al. (1980); 4, Bengtsson et al. (1988); 5, Nabarro (1987); 6, Pines et al. (1985); 7, Barzilay et al. (1991); 8, Ron et al. (1991); 9, Rajasoorya et al. (1994); 10, Cheung & Boyages (1997); 11, Orme et al. (1998); 12, Popovic et al. (1998); 13, Higuchi et al. (2000); 14, Baris et al. (2002); 15, Holdaway et al. (2004); 16, Ayuk et al. (2004); 17, Kurimoto et al. (2008); 18, Gullu et al. (2010); 19, Bałdys-Waligórska et al. (2010); 20, Kauppinen-Mäkelin et al. (2010); 21, Arosio et al. (2012); 22, Dagdelen et al. (2014); 23, Mercado et al. (2014); 24, Petroff et al. (2015); 25, Cheng et al. (2015); 26, Dal et al. (2016); 27, Maione et al. (2017).
- © 2017 Society for Endocrinology
