Progression-free survival as a surrogate endpoint in advanced neuroendocrine neoplasms

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   Figure 1

   Flow chart of studies included in the systematic review of the literature. NEC, neuroendocrine carcinoma; OS, overall survival.
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   Figure 2

   Correlation between PFS and OS. The gray area indicates the 95% confidence interval. r_s denotes Spearman’s rank correlation coefficient. OS, overall survival; PFS, progression-free survival.
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   Figure 3

   Correlation between the trial-level difference of PFS and that of OS. The gray area indicates the 95% confidence interval. r_s denotes Spearman’s rank correlation coefficient. OS, overall survival; PFS, progression-free survival.

• © 2017 Society for Endocrinology