Comprehensive screening for PD-L1 expression in thyroid cancer
- Soomin Ahn1,*,
- Tae Hyuk Kim2,*,
- Sun Wook Kim2,
- Chang Seok Ki3,
- Hye Won Jang4,
- Jee Soo Kim5,
- Jung Han Kim5,
- Jun-Ho Choe5,
- Jung Hee Shin6,
- Soo Yeon Hahn6,
- Young Lyun Oh7⇑ and
- Jae Hoon Chung2⇑
- 1Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea
- 2Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 3Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 4Department of Medical Education, Sungkyunkwan University School of Medicine, Seoul, Korea
- 5Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 6Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 7Department of Pathology and Translational genomics, Sungkyunkwan University School of Medicine, Seoul, Korea
- Correspondence should be addressed to Y L Oh or J H Chung; Email: bijou{at}skku.edu or thyroid{at}skku.edu
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Figure 1
(A) Tonsillar squamous epithelium used as the positive control for PD-L1 staining. (B–D) PD-L1 staining in papillary thyroid cancers. (B) PD-L1-negative staining. (C) PD-L1-positive staining in tumor cells with intensity 2+ and 1+ and (D) PD-L1-positive staining in intratumoral lymphocytes. A full colour version of this figure is available at http://dx.doi.org/10.1530/ERC-16-0421.
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Figure 2
(A–C) PD-L1 staining in follicular thyroid carcinomas: (A) PD-L1-negative staining, (B) PD-L1-positive staining in tumor cells with intensity 3+ and 2+ and (C) PD-L1-positive staining in tumor cells with intensity 3+ and 2+. (D–F) PD-L1 staining in anaplastic thyroid carcinomas: (D) PD-L1 negative staining, (E) PD-L1-positive staining in tumor cells with intensity 3+ and 2+, and (F) PD-L1-positive staining in tumor cells with intensity 3+. A full colour version of this figure is available at http://dx.doi.org/10.1530/ERC-16-0421.
- © 2017 Society for Endocrinology
