Figure 4
Proposed mechanism of androgen independency in CRPC. (A) Mutated AR binding to alternative steroids or antiandrogen and AR-Vs act through androgen independent pathway of CRPC. (B) Higher association with other TFs like MYC, NF-кB and STAT family members affects AR recruitment to DNA and/or regulates AR target gene expression. (C) In bypass pathway, overexpression of anti-apoptotic Bcl-2 family of proteins prevents prostate cells from death despite of ADT.
