Genetic variants in thyroid cancer distant metastases

  1. Matthew D Ringel1,6⇑
  1. 1Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus, OH, USA
  2. 2Center for Biostatistics and Department of Bioinformatics, The Ohio State University, Columbus, OH, USA
  3. 3Division of Human Genetics, The Ohio State University, Columbus, OH, USA
  4. 4Department of Pathology, The Ohio State University, Columbus, OH, USA
  5. 5Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Italy
  6. 6Department of Molecular Virology, Immunology, and Genetics, The Ohio State University Wexner Medical Center and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA
  7. 7Guardant Health, Inc, Redwood City, California, USA
  8. 8Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
  9. 9Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
  1. (Correspondence should be addressed to M D Ringel; email: matthew.ringel{at}osumc.edu)
  1. View larger version:
    Figure 1

    Schematic of the filtering criteria used on the genomic data to identify genes mutated in pathological samples. Five genes met an additional requirement that the gene had to be present in more than one sample.

  2. View larger version:
    Figure 2

    Candidate genes and variants found uniquely in more than one of 14 tumor tissue samples (primary or metastatic) vs normal tissues following filtering. One sample did not include a mutation in any of the analyzed genes.

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  1. doi: 10.1530/ERC-16-0351 Endocr Relat Cancer 23 L33-L36
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