Hypoxia-induced VEGF production ‘RSUMEs’ in pituitary adenomas
- Endocrine Signalling Group, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
1Department of Internal Medicine II, University‐Hospital Munich‐Grosshadern, University of Munich, Marchioninistraße 15, 81377 Munich, Germany
- (Correspondence should be addressed to R C Fowkes; Email: rfowkes{at}rvc.ac.uk)
Abstract
Angiogenic markers in pituitary adenomas remain enigmatic in terms of their function in tumorigenesis, despite being upregulated by the normal physiological trigger of hypoxia. In this issue of Endocrine-Related Cancer, Shan et al. report that the novel RWD domain containing protein, RWD-containing sumoylation enhancer, is expressed in human pituitary adenomas and plays a pivotal role in regulating the hypoxia-inducible factor 1α–vascular endothelial growth factor response to hypoxia.
- Revision received 19 September 2011
- Accepted 18 October 2011
- Made available online as an Accepted Preprint 18 October 2011
- © 2012 Society for Endocrinology
