Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms

1. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 1

   (a) Well-differentiated neuroendocrine tumour. (b) Poorly differentiated neuroendocrine carcinoma.
2. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 2

   Well-differentiated neuroendocrine neoplasms of the stomach: (a) multiple small polypoid tumours in the corpus region of the stomach associated with chronic atrophic gastritis of the oxyntic mucosa (type 1 gastric NET). (b) ECL cell hyperplasia in the oxyntic mucosa with microtumours. (c) ECL cell hyperplasia in patients with MEN1. (d) Type 3 NEN of the stomach with infiltration of muscular wall.
3. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 3

   Relative ratios of neuroendocrine tumours of the duodenum defined by their hormone expression. Neuroendocrine tumour archives of the Department of Pathology, University of Kiel, 1970 and 2006. Reproduced with kind permission from Springer Science+Media: Virchows Archiv, Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors, volume 451 supplement 1, ppS9–S27, Klöppel et al. (2007).
4. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 4

   Well-differentiated neuroendocrine tumour of the duodenum producing gastrin. Duodenal mucosa showing a small submucosal tumour.
5. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 5

   Gangliocytic paraganglioma showing triphasic cellular differentiation: Ganglion cells (center), endocrine cells (left) and Schwann cells (right).
6. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 6

   (a) Small neuroendocrine carcinomas (arrows) of the ileum with large lymph node metastasis in the mesenterium. (b) The tumour infiltrates the muscular layer and produces serotonin.
7. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 7

   Well-differentiated serotonin-producing neuroendocrine carcinoma of the appendix with infiltration of the mesoappendix and angioinvasion.
8. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 8

   Pancreatic neuroendocrine tumours: (a) tumour with a diameter of 2 cm (insulinoma without metastases), (b) large malignant tumour (>2 cm) in the head of the pancreas (malignant insulinoma with metastases). Reproduced with kind permission from Springer Science+Media: Virchows Archiv, Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors, volume 451 supplement 1, ppS9–S27, Klöppel et al. (2007).
9. View larger version:

   • In this window
   • In a new window

   • Download as PowerPoint Slide

   Figure 9

   Insulinomatosis of the pancreas showing multiple microtumours staining for insulin.

• © 2011 Society for Endocrinology