Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3

  1. Jay H Fowke1,
  2. Charles E Matthews1,
  3. Herbert Yu2,
  4. Qiuyin Cai1,
  5. Sarah Cohen3,
  6. Maciej S Buchowski4,
  7. Wei Zheng1 and
  8. William J Blot1,3
  1. 1Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Avenue, 6th floor, Nashville, Tennessee 37203-1738, USA
    2Yale University, New Haven, Connecticut, USA
    3International Epidemiology Institute, Rockville, Maryland, USA
    4Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  1. (Correspondence should be addressed to J H Fowke; Email: jay.fowke{at}vanderbilt.edu)
  1. View larger version:
    Figure 1

    IGF levels by BMI and race. Test for trend (African–American and white; respectively, where BMI>22): IGF1: P<0.01, P<0.01; IGF2: P=0.15, P=0.06; IGFBP3: P=0.66, P=0.40; free IGF1: P<0.01, P<0.01, adjusted for age, height, BMI at age 21 years, and menopausal status.

  2. View larger version:
    Figure 2

    IGF levels by BMI at age 21 years and race. Test for trend (African–American and white; respectively): IGF1: P=0.33, P=0.81; IGF2: P=0.38, P=0.71; IGFBP3: P=0.18, P=0.83; free IGF1: P=0.98, P=0.53, adjusted for age, BMI, menopausal status, and BMI at age 21 years.

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  1. Published online before print September 28, 2009, doi: 10.1677/ERC-09-0023 Endocr Relat Cancer March 1, 2010 17 51-60
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