Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

    1. Derek LeRoith
    1. Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    1. (Correspondence should be addressed to D LeRoith; Email: derek.leroith{at}mssm.edu)

    Abstract

    Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metformin and exogenous insulin, used to treat T2D may affect the risk of cancer and cancer-related mortality. Newer therapies targeting the insulin and IGF1 systems are being developed for use in cancer therapy.

    • Revision received 17 January 2012
    • Accepted 20 January 2012
    • Made available online as an Accepted Preprint 16 May 2012
    | Table of Contents

    This Article

    1. doi: 10.1530/ERC-11-0374 Endocr Relat Cancer 19 F27-F45
    1. Abstract
    2. Figures Only
    3. Full Text
    4. Full Text (PDF)
    5. All Versions of this Article:
      1. ERC-11-0374v1
      2. 19/5/F27 most recent

    Article Metrics

    1. Article Usage Statistics

    New Articles: issue in progress

    1. July 2018, 25 (7)
    1. Current Issue
    1. Alert me to new issues of Endocrine-Related Cancer

    Most