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This Article Full Text Full Text (PDF) All Versions of this Article: ERC-09-0108v1 17/1/R75    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Basu, B. Articles by Corrie, P. Search for Related Content PubMed PubMed Citation Articles by Basu, B. Articles by Corrie, P.

Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

(Correspondence should be addressed to P Corrie; Email: pippa.corrie{at}addenbrookes.nhs.uk)

Systemic therapy is one of a number of treatment options routinely used in the management of advanced, unresectable neuroendocrine tumours (NETs). In contrast to many of the other NET treatment modalities, there is at least some evidence base to justify its use. Even so, well-designed clinical trials are limited, since conducting clinical research in this complex group of rare cancers is challenging. The remit of this review article is to summarise the oncology literature and explain the role of systemic therapy in treating NETs of gastroenteropancreatic origin, identifying benefits and limitations. The molecular biology of NETs is now being unravelled, which affords new opportunities for development of mechanism-driven therapies. The rationale for some of the newer systemic targeted therapies that are showing promise in the clinic is discussed.