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Life Sciences Division, 1 Cyclotron Road, MS 977-225A, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA

(Requests for offprints should be addressed to M H Barcellos-Hoff; Email: MHBarcellos-Hoff{at}lbl.gov)

Transforming growth factor ß (TGF-ß) is a ubiquitous cytokine that plays a critical role in numerous pathways regulating cellular and tissue homeostasis. TGF-ß is regulated by hormones and is a primary mediator of hormone response in uterus, prostate and mammary glands. This review will address the role of TGF-ß in regulating hormone-dependent proliferation and morphogenesis. The subversion of TGF-ß regulation during the processes of carcinogenesis, with particular emphasis on its effects on genetic stability and epithelial to mesenchymal transition, will also be examined. An understanding of the multiple and complex mechanisms of TGF-ß regulation of epithelial function, and the ultimate loss of TGF-ß function during carcinogenesis, will be critical in the design of novel therapeutic interventions for endocrine-related cancers.

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