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  1. ...transporters and TR action in the brain. Journal of Endocrinology (2011) 209, 1–8 (HPT) axis and thyroid hormone metabolism by liver and brain deiodinase enzymes (deiodinase type 2 (D2) and deiodinase type 3 (D3)) to ensure basal levels are sustained (Zoeller et al. 2007)).there is a steady supply of maternal...
  2. ...occur concomitant with a changing hormonal environment as the fetus prepares itself for the transition to extrauterine life. There are complex interactions between endocrine, hemodynamic and nutritional regulators of cardiac development. Birth has been long assumed to be the trigger for major...
  3. ...and endocrine actions in http://.endocrinology-journals.org 2014 Society for Endocrinology DOI: 10.1530/JOE-14-0025 Printed in Great Britainpreventing feto-placental over exposure to thyroid hormones at critical stages of development. Another important pathway in thyroid hormone metabolism in utero...
  4. ....4 208.8G32.0b 98.8G16.8a antly different from each other (P!0.05).activity in the cerebral cortex of the sheep fetus in order to preserve local production of T3 important for normal brain development (Polk et al. 1988). The changes in bone structure seen in sheep fetuses normally during the last third...
  5. ...Figure 1 Diagram of the mouse Dlk1/Dio3 region. (A) Schematic mdemonstrated an inverse correlation in gene expression between the paternally imprinted Dio3 gene and the maternally imprinted Dio3os gene. A critical role has been attributed to the genomic region containing Dio3 during development. This DNA...
  6. ...controls the resistance of microtubules to fixation at low temperature. International Journal of Developments in Neuroscience 2 427–436. Farsetti A, Robbins J & Nikodem V 1991 Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain. Journal of Biological...
  7. ...for Endocrinology Printed in Great Britain DOI: 10.1677/.1.06680 Online version via http://www.endocrinology-journals.org Astrocytes are mediators of thyroid hormone metabolism in the brain The importance of thyroid hormone for normal brain development is well documented. Hypothyroidism during the early stages...
  8. ...expression The combination of low serum TH and an inappropriately low TSH response suggests central down-regulation of the HPT axis. This is supported by the observation that TRH gene expression in the paraventricular nucleus (PVN) of the hypothalamus was decreased in post mortem hypothalamic tissue...
  9. ...in the peripheral circulation and gonadotropinreleasing hormone (GnRH) in portal blood, development of immunohistochemical techniques to localize neuropeptides and neurotransmitters in the hypothalamus, application of techniques in molecular endocrinology to the study of gene expression in the hypothalamus and mode...
  10. ...in thyroid hormone metabolism the remarkable preference of D1 for reverse T3 (rT3) as the enzymatic outer-ring deiodination substrate, as well as the deiodination of sulfated iodothyronines, argues for its role as aunderlying its effects on normal thyroid hormone metabolism and pathological processes...
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