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  1. ...) to the cytoskeleton (El-Bahrawy & 375 Pignatelli 1998). Along the same line, SOX2 is able to sequester β-catenin, thus creating a higher 376 threshold for canonical WNT/β-catenin signaling to occur within the pituitary stem cells (Kelberman 377 et al. 2008; Alatzoglou et al. 2011). On the other hand, the β-catenin...
  2. ...with that for control animals, indicating elevated stem cell Discussion * * 0.4 0.2 0.0 β-catenin c-Myc GSK3β GLUT1 p-ERK Akt Caspase 3 Figure 1 Relative expression of b-catenin, caspase 3, GSK3b, c-Myc, ERK, Akt, and GLUT1 protein, as determined by western blot analysis. A significant upregulation of Wnt...
  3. ...stem cells (NSCs). However, little is known about the molecular mechanisms by which ghrelin regulates cell cycle progression. The purpose of this study was to investigate the potential effects of ghrelin on cell cycle regulatory molecules in cultured hippocampal NSCs. Ghrelin treatment increased...
  4. ...transforming growth factor-beta isoforms on pituitary lactotropic cell proliferation. Endocrinology 141 1528–1535. (doi:10.1210/en.141.4.1528) Itoh F, Watabe T & Miyazono K 2014 Roles of TGF-beta family signals in the fate determination of pluripotent stem cells. Seminars in Cell and Developmental Biology 32...
  5. ...defects of early pituitary development resulting in impaired GH secretion that have been described in mice by targeted gene disruption and in humans by candidate gene sequencing including HESX1, SOX2, SOX3, LHX4, PITX2 and OTX2 (for review, see Kelberman et al. (2009)). Increasingly, there has been...
  6. ...mass in part by altering adipogenesis of MSCs. Keywords growth hormone adipose tissue-derived mesenchymal stem cells adipogenesis Wnt/β-catenin signaling Introduction Recent studies have indicated that healthy adipose tissue (AT) expansion, especially of the subcutaneous (sc) fat depot, is essential...
  7. ... C, Hwang Y-S & Varghese S 2009 Mesenchymal stem cell differentiation and roles in regenerative medicine. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 1 97–106. (doi:10.1002/wsbm.26) Ilmiawati C, Horiguchi K, Fujiwara K & Yashiro T 2012 Matrix metalloproteinase-9 expression...
  8. ...SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5. European Journal of Endocrinology 152 645–654. (doi:10.1530/eje.1.01876) Hofland LJ, Feelders RA, de Herder WW & Lamberts SW 2010a Pituitary tumours: the sst/D2 receptors as molecular targets...
  9. ...and the effects of this interaction on the biological functions of " superoxide dismutasebiological effects of melatonin in mesenchymal stem cells Fan He1,2,3,*, Xiaozhen Liu1,*, Ke Xiong4, Sijin Chen4, Long Zhou2,3, Wenguo Cui2,3, Guoqing Pan2,3, Zong-Ping Luo2,3, Ming Pei5 and Yihong Gong1 1School...
  10. ...Endocrinology 332 242–252. (doi:10.1016/j.mce.2010.10.019) Hollnagel A, Oehlmann V, Heymer J, Ruther U & Nordheim A 1999 Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. Journal of Biological Chemistry 274 19838–19845. (doi:10.1074/jbc.274.28.19838) Huang HJ, Wu...
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