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  1. ...problematic for Kugelberg and colleagues who were unable to sex them at 3 weeks of age 441 and therefore had to use both males and females in their study (Kugelberg et al. 2005). This 442 is important as imprinting (Jansson et al. 1985) by androgen secretion of the neonatal rodent 443 Page 18 of 54 19 brain ~~~
  2. ...of thyroid hormone on some 434 electrophysiological properties of developing rat skeletal muscle cells in culture. Brain Res294 435 75-82. 436 Barbe P, Larrouy D, Boulanger C, Chevillotte E, Viguerie N, Thalamas C, Oliva Trastoy M, 437 Roques M, Vidal H & Langin D 2001 Triiodothyronine-mediated up ~~~
  3. ..., but also by isocitrate dehydrogenase 2 (Idh2) 491 and malic enzyme 3 (Me3) we excluded a possible compensatory mechanism, as 492 expression levels of these enzymes remain unchanged between Nnt+/+ and Nnt-/- mice. 493 Studies by other groups have similarly demonstrated that liver, heart, brain, and skeletal ~~~
  4. ..., Jorgensen etal. 2013). Notably, brain-specific or muscle-specific SOCS3 ablation improves insulin sensitivity and may partially prevent diet-induced obesity (Mori etal. 2004, Jorgensen etal. 2013, Pedroso etal. 2014). These effects occur because SOCS3 inhibits several cytokines/hormones that regulate ~~~
  5. ...Research), partner site Hamburg/Kiel/Lbeck, 5 Lbeck, Germany, CBBM (Center of Brain, Behavior and Metabolism), Lbeck, Germany 6 7 8 Running title: S1P and aldosterone release II 9 Word count: 5808 10 11 12 Corresponding author: 13 Walter Raasch, Ph.D, Institute of Experimental and Clinical Pharmacology ~~~
  6. ...brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE 6 e25231. (doi:10.1371/journal.pone.0025231) Suresh KP 2011 An overview of randomization techniques: an unbiased assessment of outcome in clinical research. Journal of Human Reproductive Science 1 ~~~
  7. ...). Another pioneer investigator stated that intraosseous blood flow gives life to bone, just as intracerebral blood flow gives life to the brain and coronary blood flow life to the heart (Laroche 2002). Additionally, Brookes and Lloyd (1961) theorized that bone formation occurs only in relation to blood ~~~
  8. ..., Rivier J & Vale W 1981 Somatostatin-28: selective action on the pancreatic beta-cell and brain. Endocrinology 108 23912396. (doi:10.1210/endo-108-6-2391) Bruns C, Lewis I, Briner U, Meno-Tetang G & Weckbecker G 2002 SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting ~~~
  9. ...Jhren2, JensMittag1, HendrikLehnert1 and CarlaSchulz1 1Department of Internal Medicine I, Center of Brain, Behavior and Metabolism (CBBM), University of Lbeck, Lbeck, Germany 2Center of Brain, Behavior and Metabolism (CBBM), University of Lbeck, Lbeck, Germany Abstract Nesfatin-1 is a bioactive ~~~
  10. ...RNA level in mesenteric arteries is several times lower than that in saphenous artery. The D2 mRNA level was shown to correlate with the D2 enzyme activity in brain, skeletal muscle and brown adipose tissue of rats (Nagao et al. 2014). Assuming such correlation in vascular tissue, we would expect lower D2 ~~~
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