...NUCB2 ~~~

...NUCB2 and/or nesfatin-1. Furthermore, nesfatin-1 exerts pleiotropic actions at the level of cardiovascular and digestive systems, as well as plays a role in stress response, behavior, sleep and reproduction. Despite the recent advances in nesfatin-1 research, a putative receptor has not been identif ~~~

...NUCB2 and nesfatin-1 are expressed in human adrenal gland and human adrenocortical cells (H295R). Stimulation with nesfatin-1 inhibits the growth of H295R cells and promotes apoptosis, potentially via the involvement of Bax, BCL-XL and BCL-2 genes as well as ERK1/2, p38 and JNK1/2 signalling cascade ~~~

...NUCB2 by prohormone convertases, the enzymes that process proinsulin (Oh-I et al. 2006). Nesfatin-1 immunoreactivity (ir) has been reported in the rat pancreas blood glucose levels, and endogenous nesfatin-1 is altered in diabetes. Other studies in this emerging area primarily focused onwith type 2 ~~~

...NUCB2 reports, appear more compatible with intracellular actions rather than with endocrine/paracrine communication, and pancreas (Kulkarni et al. 1995, Yamada et al. 1997). A recent addition to the group of centrally acting catabolic signalling feeding and concomitant reduction in body weight. neur ~~~