Figure 2
Model for the role of endothelial cell-mineralocorticoid receptor (EC-MR) in vascular function. In the presence of cardiovascular disease risk factors, such as diabetes, obesity and hypertension, EC-MR contributes to endothelial dysfunction via endothelial nitric oxide synthase uncoupling, NADPH oxidase (Nox) activation, increases in epithelial sodium channel expression and inflammation via ICAM-1-mediated leukocyte adhesion. ICAM-1; intracellular adhesion molecule-1. ROS; reactive oxygen species. NO; nitric oxide. eNOS; endothelial nitric oxide synthase. ENaC; epithelial sodium channel.
