Supplementary Figure

Files in this Data Supplement:

• Supplementary Figure 1 - Resveratrol and curcumin enhance insulin secretion in mouse β-Min6 insulinoma cells. Mouse β-Min6 cells were treated with RES, CUR, or RES+CUR for 24 hrs under low (1 mmol L^-1) or high (25 mmol L^-1) glucose conditions at the indicated doses. Supernatants from triplicate samples were analyzed for insulin secretion upon normalizing to protein (* p < 0.05, **** p < 0.0001). Data is representative from at least three independent experiments. (PDF 558 KB)
• Supplementary Figure 2 - Resveratrol and curcumin enhance insulin secretion in human pancreatic islets. Primary human islets (n = 2 donor) were treated with RES, CUR, or RES+CUR for 2 and 24 hrs under low (5 mmol L^-1) or high (25 mmol L^-1) glucose conditions at the indicated doses. Supernatants from triplicate samples were analyzed for insulin secretion upon normalizing to protein (* p < 0.05, ** p < 0.01, **** p < 0.0001). Data is representative from at least three independent experiments. (PDF 723 KB)
• Supplementary Figure 3 - Effects of resveratrol and curcumin on intracellular cAMP production in human pancreatic islets. Primary human islets (n = 2) were treated with RES, CUR, or RES+CUR for 2 hrs under low (5 mmol L^-1) or high (25 mmol L^-1) glucose conditions at the indicated doses. Cells were lysed and assessed for intracellular cAMP levels after normalizing to protein content in triplicates (* p < 0.05). Data is representative from at least three independent experiments. (PDF 512 KB)