Supplementary Figure

Files in this Data Supplement:

• Supplementary Figure 1 - Histomorphometric analysis of the femur from SAMP6 mice showing the distinct effects of intermittent treatment with 1-34 PTH at a standard and low dose on bone volume (A), trabecular thickness (B), trabecular number (C) and trabecular separation (D). Mean+/- SD of 6-8 mice. * indicates statistical significance (P<0.05). (PDF 48 KB)
• Supplementary Figure 2 - Histomorphometric analysis in vertebrae from SAMP6 mice showing no effect of low dose 1-34 PTH on the osteoblast surface (A) and TRAP+ osteoclasts (B). Mean+/- SD of 6-8 mice. N.S.: No statistical significance. (PDF 30 KB)
• Supplementary Figure 3 - Histomorphometric analysis of the femur in senescent osteopenic SAMP6 mice showing that 1-34 PTH at low dose increased mineral apposition rate (MAR) (A) but not the double labeled surface (B) or bone formation rate (C) which were all increased at the standard dose. Mean+/- SD of 6-8 mice. * indicates statistical significance (P<0.05). (PDF 43 KB)
• Supplementary Figure 4 - Effect of low dose PTH on Wnt signalling effectors in prematurely senescent osteopenic SAMP6 mice. Quantitative RT-PCR analysis of specific Wnt effectors was performed in bone marrow stromal cells and osteoblasts/osteocytes extracted from long bones in control SAMP6 mice or mice treated with PTH at low dose for 6 weeks. The transcript levels were normalized to HRPT values. Mean+/- SD of 6-8 mice. * indicates statistical significance (P<0.05). (PDF 43 KB)