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Figure 2

Different HS structures support different biological activities. (A) Heparan sulphate that has different cell- and tissue-specific structures (denoted schematically by red, yellow and green bars) with binding domains for different growth factors. Here, green represents structures that are capable of binding to both FGF and FGFR, thus supporting ligand-induced dimer formation and consequent signalling in the FGFR complexes. Yellow structures cannot bind to FGF or FGFR, but are capable of binding to PDGF and regulating its activity. Red structures can bind to FGF, but cannot support subsequent binding to FGFR. (B) Heparan sulphate that lacks the required structures (green) cannot support FGF signalling through FGFR, although the presence of other structures (red) still allows it to bind to FGF without supporting its activity. Other structures (yellow) may bind and regulate PDGF, mediating alternative signal pathway.

This Article

  1. Published online before print February 9, 2011, doi: 10.1530/JOE-10-0377 J Endocrinol vol. 209 no. 2 139-151
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