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This Article Full Text Full Text (PDF) All Versions of this Article: JOE-08-0294v1 199/2/151    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kassi, E. Articles by Papavassiliou, A. G PubMed PubMed Citation Articles by Kassi, E. Articles by Papavassiliou, A. G

Department of Biological Chemistry, University of Athens Medical School, 75, Mikras Asias Street, 11527 Athens, Greece

(Correspondence should be addressed to A G Papavassiliou; Email: papavas{at}med.uoa.gr)

Recent studies have indicated a novel function for skeleton unraveling its importance in the control of energy metabolism. In the present commentary, we speculate on the meaning for bone to act as a ‘rheostat’ modulating glucose metabolism, and how the primitive way of communication between bone and energy metabolism through switch on/off genes (like Ptprv) evolved to a more complicated ‘talking’ via gain/loss of hormones activity (like osteocalcin) by carboxylation/decarboxylation process.